Effect Of Body Mass Index At Diagnosis On Early Treatment Outcome Of Children With Acute Lymphoblastic Leukemia

Objective:Research on effect of body mass index(BMI)at diagnosis on early treatment outcome of children with acute lymphoblastic leukemia(ALL).Method:Clinical data of 156 patients,diagnosed between December 2015 and June 2017,is collected in First affiliated hospital of Xinjiang Medical university.Based on different BMI level,patients are classified as underweight,normal weight,overweight or obese.All patients are treated with remission induction therapy according to “Guidelines of prognosis and treatment of children with acute lymphoblastic leukemia(the fourth edition)”.Complete bone marrow morphological examination and monitoring of minimal residual disease(MRD)at the end of remission induction therapy(on day 33).Retrospectively analyse effect of BMI at diagnosis on early treatment outcome of children with ALL.Results:Complete remission rate of bone marrow on day 33 of remission induction therapy is 93.6%,while MRD negative rate at the same time is 90.4%.Both complete remission rate and MRD negative rate of patients classified as underweight,overweight and obese are lower than that of normal weight patients.No significant difference is found between different BMI level and complete remission rate(P=0.578).Whereas difference between different BMI level and MRD negative rate is statistically significant(P=0.011).Conclusion:The early treatment outcome of underweight,overweight,and obese patients is worse than normal weight patients.Inappropriate BMI level at diagnosis can be defined as an adverse indicator for ALL patients.