Analysis Of Multiple Factors That Influence The Prognosis Of Childhood Acute Lymphoblastic Leukemia

Objective:To analyses the treatment outcome of childhood acute lymphoblastic leukemia(ALL) patients in the Childhood Hospital Of Qingdao & the Affiliated Hospital of Qingdao University,and explore the prognostic factors of childhood ALL of long outcome.Methods:76 cases who aged less than 15 years old and were initially diagnosed from January 1,1998 to July 1,2003 in pediatric hematology of our hospitals were carried out the survival study with retrospective cohort method,all the first continuous course treatments were over 6 months after final diagnosis and could be follow-up visited.The 5 years event-free survival(5-EFS) was estimated by Life-Tables.The single and multivariate COX Regression analysis of the whole subjects showed the prognostic factors, Kaplan-Meier was used to analyses the change of EFS and hazard in the prognostic factors,the relation of the prognostic factors was treated by Pearsonχ~2 Test.All the data were carried by SPSS-16.Results:Out of the 76 cases,the remission induction rate of childhood ALL was 94.7%,the amount of recurrence were 20 and the recurrence rate is 26.32%,the median survival time was 86 months,and the 5-year-event-free survival(5-EFS) was(70±1.23)%.The multivariate COX Regression analysis of the whole subjects showed that the prognostic factors increased the risk of survival including the first peripheral white blood cells(PWBC)count(≥50×10~9/L),bad response to prednisone,protymphocyte percent in bone marrow(BM) on the 35th day of induction therapy(≥5%),recurrence after remission,treatment of noncompliance.Conclusions:the first PWBC,response to prednisone,the 35th day prolymphocyte percent in BM,recurrence after remission and treatment of noncompliance are the independent prognostic factors for childhood ALL.