Application Of Traditional Chinese Medicine Characterized Chronic Disease Management In Non-alcoholic Fatty Liver Disease

Objectives To observe the effect of traditional Chinese Medicine(TCM)Characterized chronic disease management in non-alcoholic fatty liver disease(NAFLD),and to explore the management mode of NAFLD chronic disease,so as to provide reference for the treatment and nursing of NAFLD.Methods According to the inclusion and exclusion criteria,101 cases of NAFLD patients were included in this study,101 patients were randomly divided into three groups by random number table: 34 cases of blank control group,34 cases of general health education group,33 cases of chronic disease management group.The control group did not take any measures,general health education group received routine health education,Chronic disease management group were taken TCM characterized chronic disease management for NAFLD patients by established TCM characterized chronic disease management health records,taken health assessment,health management,telephone consultation for them,according to the different constitutions of the subjects;and the three groups were observed for 24 weeks.The evaluation indexes included weight,waist circumference(WC),hip circumference(HIPS),waist hip ratio(WHR),body mass index(BMI),etc;the evaluation indexes were statistically analyzed before and after the test,the difference between the blank control group,general health education group and chronic disease management group was compared.IBM SPSS Statistics l9.0 was used for statistical analysis,if the measurement data satisfy both normal distribution and homogeneity of variance,T test or ANOVA was used,if not,rank-sum test was used;Enumeration data were tested by chi square test(or Fisher exact test),comparisons between groups were performed by one-way ANOVA or Nemenyi test.The tests benchmark is 0.05.Results(1)101 cases were included in the study,The average age of the volunteers was 42.87±11.14 years,54 men and 47 women were included.Among the subjects,58 cases were mild,33 cases were moderate,and 10 cases were severe.During the study,4 cases were lost,and the exfoliate rate was 3.96%.There was no significant difference in age distribution,gender composition and NAFLD level between the control group,the general health education group and the chronic disease management group(P>0.05).(2)The HIPS of control group was significantly lower than the test before(P<0.05),the WHR of control group was significantly higher than the test before(P<0.05),there was no significant difference in the basic physical indicators of health education group before and after the test(P>0.05),the weight and BMI reduction of chronic disease management group were significantly lower than that of the control group and health education group(P<0.05).The WHR reduction of the chronic disease management group was significantly different from that of the control group(P<0.05).(3)The CHOL and HDL-c of the control group and the chronic disease management group were significantly higher than those of the test before(P<0.05).The CHOL of the health education group was significantly higher than the test before((P<0.05).The HDL-c rise of the chronic disease management group was significantly different from that of the control group(P<0.05).(4)There were no significant changes in the basic physical indicators of the control group and the health education group before and after the test(P>0.05).The body fat content and visceral fat area reduction in the chronic disease management group were significantly lower than the experiment before(P<0.05).The visceral fat area reduction of the chronic disease management group was significantly different from that of the control group(P<0.05)(5)There were no significant changes in the ALT,AST and AST/ALT values of the control group and the health education group(P>0.05).The AST/ALT value of the chronic disease management group was significantly lower than the test before(P<0.05).There was no significant difference in the ALT,AST and AST/ALT between the control group,the general health education group and the chronic disease management group(P>0.05).(6)There were no significant changes in the scores of eight dimensions of SF-36 between the control group and the health education group(P>0.05).The scores of RP dimension,VT dimension and GH dimension in the chronic disease management group were significantly higher than that before the test(P<0.05).The scores of VT dimension of the chronic disease management group was significantly higher than that of the control group and the health education group(P<0.05).Conclusions The TCM Characterized chronic disease management can effectively reduce the weight,BMI,body fat content and visceral fat area and AST/ALT value of NAFLD patients,improve the quality of life of NAFLD patients,and have no obvious adverse reactions and side effects.So the TCM Characterized chronic disease management has a certain effect on the prevention and treatment of NAFLD;However its effect on the control of blood lipid in NAFLD patients needs to be further studied.