Study On Clinical Observation Of The "Changkang Decoction" In Treating Diarrhea Predominant Irritable Bowel Syndrome

Part 1:theoretical studyIn this study,we first expounded the learning and basic treatment methods of traditional Chinese medicine(TCM)and western medicine on diarrheal predominant irritable bowel syndrome(IBS-D),and summarized the current treatment status of IBS-D in TCM and western medicine.Modern medicine believes that IBS-D has complicated pathogenesis.Although there are many treatment methods,the symptoms are easy to repeat.Traditional Chinese medicine believes that IBS-D belongs to "catharsis","abdominal pain"and "depression".The basis of the disease is congenital deficiency,the acquired loss,which is often onset because of mood,diet,suffering from exogenous evils;The main position of the illness is in the intestines,mainly involves liver,spleen(stomach),kidney and other organs.Usually related to the heart and lung.The main pathogenesis of the disease is weakness of spleen and stomach,liver-qi invasion,the crucial pathogenesis of pathogenesis is liver qi invading spleen,and the key factor of the relapse is spleen-kidney yang deficiency,and mixture of asthenia and sthenia.TCM,acupuncture and coloclysis are used to treat IBS-D,which are safe and effective,providing new ideas for IBS-D research.Part 2:clinical studyOBJECTIVES:To observe the clinical curative effect of "Changkang Decoction " in the treatment of diarrheal irritable bowel syndrome,and the improvement of primary observation target(abdominal pain,diarrhea)and secondary observation target(spasmatic pain in lower abdomen,distending fullness and scurrying pain in chest and hypochondrium,borborygmus and flatus,putrid stool,depression and sighing,irritability,poor appetite)respectively.METHODS:A total of 153 IBS-D patients were randomised divided into the treatment group,77 patients were taking Changkang Decoction,and 76 patients in the control group were treated with Trimebutine Maleate capsules.After 4 weeks of treatment,both groups were treated to observe and compare the clinical efficacy and symptom score improvement.RESULTS:The total effective rate of the clinical observation group was 87.0%,and the total effective rate of the control group was 75%,with no statistically significant difference(P>0.05).The main observation targets(abdominal pain,diarrhea)efficiency of the observation group were 84.4%,which in the control group was 88.2%,with no significant difference(P>0.05).The effective rate of the secondary observation indexes(spasmatic pain in lower abdomen,distending fullness and scurrying pain in chest and hypochondrium,borborygmus and flatus,putrid stool,depression and sighing,irritability,anorexia and abdominal distension)in the treatment group was 76.6%,and the effective rate of the secondary observation indexes in the control group was 57.9%,and the difference was significant(P<0.05).After two weeks,abdominal pain,diarrhea,spasmatic pain in lower abdomen,borborygmus and flatus,putrid stool were dramatically relieved in two groups than before(P<0.01).Symptoms of abdominal pain,diarrhea,spasmatic pain in lower abdomen,borborygmus and flatus in treatment group were better than control group(P<0.05),while the improvement of diarrhea and putrid stool were on the contrary(P<0.05),spasmatic pain in lower abdomen,borborygmus and flatus were no obvious difference between two groups(P>0.05).Four weeks later,abdominal pain,diarrhea,spasmatic pain in lower abdomen,distending fullness and scurrying pain in chest and hypochondrium,borborygmus and flatus,putrid stool,depression and sighing,irritability,anorexia in each group was observably improved(P<0.01).Improvement of abdominal pain and spasmatic pain in lower abdomen in treatment group were better than control group(P<0.05),while diarrhea was just the reverse(P<0.05),all could not change abdominal distension.CONCLUSION:Changkang Decoction can be effective in the treatment of irritable bowel syndrome,working fast,significantly improve patient's abdominal pain,diarrhea,spasmatic pain in lower abdomen,distending fullness and scurrying pain in chest and hypochondrium,borborygmus and flatus,putrid stool,depression and sighing,irritability score has the good clinical curative effect.