Reseach Of The Correlation Of Gestational Diabetes And Gestational Hypertensive Disorders And Thyroid Function In The Pregnancy

Objective:The purpose of this study was to analyze the correlation between gestational age and gestational thyroid function in pregnant women with gestational hypertension,gestational diabetes mellitus,and gestational diabetes with hypertension in our hospital in 2017 through a retrospective study.To provide a theoretical basis for exploring the prevention and treatment of pregnancy complications and adverse outcomes.Methods:1206 pregnant women,which were confirmed as single live births by B ultrasound,receive treatment in Sichuan Provincial People’s Hospital between January1,2017 and December 31,2017 were studied retrospectively,The pregnant women age was range from 20 to 40,resided in Chengdu and excluded internal or surgical chronic diseases before pregnancy.324 cases of gestational diabetes,123 cases of hypertensive disorder of pregnancy,36 cases of gestational diabetes with gestational hypertension.723 cases of pregnant women with normal blood pressure and blood sugar during the second trimester Results:1.The cumulative incidence of subclinical hypothyroidism in the gestational diabetes group was 12.65%,27.46%,and 31.47% respectively during in the first trimester,second trimester,and third trimester,and 8.43%,20.19%,and 22.68% in the control group,respectively.The difference was statistically significant.(P=0.033,P=0.009,P=0.003,respectively).The cumulative incidence of hypothyroidism in the gestational hypertension group was 8.95% in the third trimester and 4.42% in the control group(P=0.035).The rate of pregnant woman with TPOAb(+)but normal thyroid gland function in the first trimester occurred in the gestational hypertension group was 25.20%.While 17.43% in the control group,The difference was statistically significant(P=0.04).2.The median FT4 values during pregnancy were decreased,TSH increased during the period of pregnancy.3.The incidence of premature rupture of fetalmembranes,neonatal asphyxia,and preterm birth in the gestational diabetes group,the gestational hypertension group,and the control group had a P value of <0.01,and the difference was statistically significant.Conclusion:1.During the second trimester,the prevalence of thyrotoxicosis,hypothyroidism,hypothyroidism,and hypo-T4 emia in the gestational diabetes group and the control group showed the highest tendency.The prevalence of hypothyroidism in the pregnancy-induced hypertension group was the highest.It is suggested that thyroid hormone levels may fluctuate in the second trimester,so it is recommended to strengthen the detection of thyroid hormone in the second trimester.2.In this study,FT4 hormone levels were downward trend during pregnancy and TSH hormone levels were on the rise.3.Compared with the control group,the prevalence of subclinical hypothyroidism in the gestational diabetes group was high during pregnancy,suggesting that subclinical hypothyroidism has a certain relationship with the incidence of gestational diabetes.Therefore,in order to prevent the development of gestational diabetes,dietary guidance and necessary blood glucose monitoring for the pregnant women with hypothyroidism were required.4.Compared with the control group,the incidence of intrauterine growth restriction,premature rupture of membranes,premature delivery,neonatal asphyxia,and postpartum hemorrhage in the three groups was higher,suggesting that complications during pregnancy are more likely to lead to adverse pregnancy outcomes,we need focus on the maternal both pre-pregnancy health care and pregnancy care.