| Objective:By collecting the postoperative data of patients after operation of colorectal cancer,comparing the differences between the left and right colorectal cancer and utilizing the method of cluster analysis,we explore the distribution patterns and characteristics of syndromes after colon cancer operation.,and further explore the correlation between syndrome types and staging,pathology,tumor markers,so as to provide new research ideas for the treatment of colon cancer with integrated traditional Chinese and Western medicine.Methods:A database is set up consisting of basic data collected by questionnaire,FACT-C score,symptoms,tongue and pulse information.In addition,SPSS 21.0 is employed in statistics to analyse differences of colorectal cancer in age,stage,pathological type,tumor marker,quality of life score and TCM syndrome.What's more,the method of cluster analysis is applied to find out,the distribution characteristics of postoperative TCM syndrome and the correlation between syndrome type and pathological stage,tumor markers,etc..Results:(1)In this study,there were more male patients with large intestine cancer,57 males and 43 females.There was no statistical significance in sex difference between the left and right colon cancer patients(P>0.05).The patients with left colorectal cancer is from 54.69 years old to 74.51years old on average;the average age o patients with right colon cancer is from 45.47 years old to 72.73years old on average,.And the difference of age distribution between patients with left and right colorectal cancer is statistically significant(P<0.05).(2)In this study,the main TNM stage is ? stage,accounting for 39%of the total,? period for 29%of the total,24%in ?,and 8%in I.The difference has no statistical meaning in the distribution of TNM staging in left and right colorectal cancer(P>0.05).(3)In this study,the pathological type of tubular adenocarcinoma with middle differentiation ranks first,accounting for 55%of the total.The majority of left colon cancer was moderately differentiated tubular adenocarcinoma,which accounted for 70%of the total left colon cancer.The right hemi colon cancer was mainly mucous adenocarcinoma,which accounted for 52%of the total right half of the colon cancer.The pathological types of left and right colon cancer were statistically significant(P<0.01).(4)In this study,the figure of CEA x±s in the left colon cancer is 11.94±5.28ug/L;the figure of CEA x±s in the right colon cancer is 14.22± 5.30 ug/L.And the difference between the CEA value of the left and right colon cancer is statistically significant(P<0.05).The difference of AFP,CA125,CA153 and CA199 of left and right colon cancer was not statistically significant(P>0.05).(5)In this study,the different scores between health state,functional state and quality of life have statistical significance(P<0.05),with statistically significant difference in scores of cancer specific module(P<0.01),and no statistical significance about colon cancer in the family status and social emotion condition score difference(P>0.05).(6)According to the results of cluster analysis,the TCM syndrome types of the patients after the operation of colon cancer were divided into six types:dampness and heat,and blood stasis resistance type two deficiency,spleen kidney yang deficiency,spleen deficiency and qi stagnation and liver kidney yin deficiency type.(7)In this study,damp heat accumulation type in left colon cancer is dominant,accounting for 34%of the total.However,spleen kidney yang deficiency,Qi deficiency and yin deficiency of liver and kidney is rare,accounting for only 10%.The liver and kidney yin deficiency in right half of the colon cancer is more common with the proportion of 32%,followed by Qi and blood deficiency which accounts for 22%.The spleen and kidney yang deficiency is the least,accounting for 8%.The difference in the distribution of syndrome type between left and right colon cancer is statistically significant(P<0.05).(8)In this,study,shireyunjiexing mainly appears ? and ?,accounting for 6%and 10%;the type of blood stasis syndrome is obvious in ? phase,accounting for 8%.The deficiency of Qi and blood two was concentrated in phase ? and ? with the proportion of 7%and 6%respectively.The asthenia of spleen and kidney was concentrated in ? stage,which accounted for 8%.The spleen qi stagnation type was concentrated in ? stage,accounting for 7%.The yin deficiency of liver and kidney was concentrated in ? stage,which accounts for 12%.The difference of TNM staging of each syndrome type was statistically significant(P<0.05).(9)In this study,the CEA figure of the spleen and kidney yang deficiency is the highest,which is 16.54±7.42 ug/L.And the rest from high to low is the deficiency of Qi and blood two,respectively.15.11±3.5ug/L.Yin deficiency of liver and kidney is 14.79±5.47 ug/L.Blood stasis syndrome type of internal resistance is12.53±4.71 ug/L.shireyunjiexing is 11± 4.14 ug/L;spleen qi stagnation type,the value was 10.25 ± 5.74ug/L.The difference between the CEA values of each type of syndrome was statistically significant(P<0.05).The CA199 value was the highest in the Stasis Toxin internal resistance type,which was 44.56+ 6.87 U/ml,higher than the remaining 5 syndromes,and the CA199 difference between the different syndromes was statistically significant(P<0.05).There was no significant difference in the values of AFP,CA125 and CA153 among the syndromes(P>0.05).(10)The collection of cases,the quality of life score shireyunjiexing ranks first,101.82 ±3.16,followed according to following order:97.81 ±3.23 points of blood stasis syndrome,91.63± 3.42 points of spleen qi stagnation type,90.44±3.33 points of Qi and blood two deficiency,90.29±3.35 points of liver kidney yin deficiency,89.67±2.92 points spleen and kidney yang deficiency.The difference of the score of each type of life quality was statistically significant(P<0.05).Conclusion:(1)There are great differences in age,pathological type,CEA,CA199,quality of life score and TCM syndrome differentiation between left and right colorectal cancer.To explore the difference of left and right colon cancer can help the diagnosis of colon cancer,and it can play a guiding role in the differentiation and treatment of colon cancer.(2)There were differences in the scores of the stages,CEA,CA199 and the quality of life score among the various syndromes of colorectal cancer.To explore the relationship between the syndrome types of colon cancer and the related factors can promote the objective process of TCM syndrome differentiation,and provide a new entry point for the combination of traditional Chinese and Western medicine in the treatment of colon cancer. |
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