The Clinical Study On The Patients With Primary Dysmenorrhea Of Coagulopathy

Objective:to observe the effectiveness,safety and recurrence of menstruation regulating and pain relieving method in treating primary dysmenorrhea of congealing cold blood stasis and its influences on relevant endocrine hormone,initially discuss the mechanism of action of menstruation regulating and pain relieving method on primary dysmenorrhea,seek a more feasible scheme for the disease and provide objective basis for clinical treatment.Method:collect 60 primary dysmenorrhea of congealing cold blood stasis patients in Gynecology Department of Nanjing Hospital of Chinese Medicine and randomly divide them into two groups with each group containing 30 patients.Treatment group was offered menstrual period prescription,postmenstrual period prescription,intermenstrual period prescription and premenstrual period prescription according to their menstrual phase;control group was offered Yueyueshu from one week before menstruation to the third day of menstruation;a course is three months for both groups.Observe the changes of dysmenorrhea VAS scores,COX dysmenorrhea scores table,Chinese medicine symptom complex score,prostaglandin and other indexes.Adopt SPSS20.0 statistical software to process data,judge clinical curative effects through before-after control and group control,and discuss the mechanism of action of menstruation regulating and pain relieving method.Results:treatment group has a higher effective rate than that of control group;treatment group has a better improved dysmenorrhea scores than control group;treatment group has a shorter dysmenorrhea time than control group;treatment group has better improved TCM symptoms than control group;treatment group has better effects on P level in rising luteal phase and E 2 level in decreasing luteal phase than control group;treatment group has better effects on lowering PGF2a and improving PGE2 concentration than control group;the follow-up visit within three months after treatment shows that treatment group has a lower long-term recurrence rate than control group.Conclusion:it was observed clinically that menstruation regulating and pain relieving method can improve P and PGE2 level in luteal phase,lower E2 and LGF2a level in luteal phase and improve dysmenorrhea by regulating the factors relating to the female reproductive endocrine.The method has real curative effects on primary dysmenorrhea of congealing cold blood stasis and less bad effects.And the method still has long-term curative effects after drug withdrawal.