Effects Of Lotus Leaf And Black Tea On Lipid Metabolism And Colorectal Cancer Related Molecules In Patients With Endogenous Damp-heat Syndrome

Purpose:To study the effects of lotus leaf and black tea on the levels of blood glucose,blood lipid,inflammatory factors and colorectal neoplasms in patients with endogenous damp-heat syndrome.Methods:In order to improve the research efficiency,Self-controlled method was adoptedinthestudy.Included 31 patients with dyslipidemia and endogenous damp-heat syndrome,after health education,drinking lotus leaf and black tea in the original unchanged lifestyle.They were treated for one month and then would follow up after treatment.Results:(1)In the traditional Chinese medicine symptoms,it can significantly improve the symptoms of endogenous damp-heat syndrome after treatment,The symptom score was significantly decreased compared with prior treament(P<0.05);(2)In general,There was the significant difference in blood pressure(BP)(P<0.05),the body mass index(BMI)was lower than that before treatment while there was no significant difference in the improvement of waist hip ratio(WHR)(P>0.05);(3)Lipid metabolism indexs:after treatment,there is a decreasing tendency in Triglyceride(TG)and increasing tendency in high density lipoprotein(HDL-C),there was no significant difference in cholesterol(TC)and low density lipoprotein(LDL-C)(P>0.05);(4)Glucose metabolism indexs:Fasting plasma glucose(FPG),fasting insulin(FINS)and insulin resistance(IR)are decreased compared with prior treatment;(5)Inflammatory factors:There was the significant difference in tumor necrosis factor(TNF-a),(P<0.05),the IL-1 decreased as cmpared with those before treatment;(6)The relevant indicators of colorectal cancer:Insulin-like growth factor binding protein-3(IGFBP-3)and leptin were significantly decreased;the insulin growth factor 1(IGF-1)had no significant effect(P>0.05).Conclusion:Lotus leaf and black tea can significantly improve the hot and humid intrinsic symptoms in patients with endogenous damp-heat syndrome,lower blood pressure in patients,reduce TC,elevate HDL-C,and improve insulin resistance;it also can reduce the inflammatory factor TNF-?,IL-1 and tumor-related indicators IGFBP-3,Leptin,and may play a role in the prevention of diet-related tumors such as colorectal cancer,but the mechanism still needs further exploration.