Analysis The Clinical Efficacy Of Chronic Atrophic Gastritis Treated By Manwei Particless Based On The Theory Of Host-guest Interaction

Objective:The theory of host-guest interaction,it is thought that human morbidity is due to be shor of righteousness,and the evil influence,but the weak righteousness cannot escape the evil to cause the evil inflence and blood wrapped around each other in the veins.This is very similar to the pathogenesis of chronic atrophic granules.Therefore,this study is based on the theory of "host-guest interaction " to observe the clinical curative effect of the in-hospital preparations-Manwei particless that was researched and developed by many years of clinical experienceby of Professor Zhou deduan who a deceased old doctor of our hospital.In particular,the changes of serum pepsinogen I(PGI),pepsinogen II(PGII)and the ratio of PGI and PGII(PGR)before and after the treatment.Methods:Screening a total of 80 patients with chronic atrophic gastritis who visited our hospital from October 2015 to October 2017(The main symptomsall is stomach bliges,and belong to spleen and stomach weak and qi stagnation and blood stasis).According to the principle of randomization,it was divided into treatment group(Manwei particless group)and control group(Weifuchun tablets group),and 40 cases each.The control group was given Weifuchun tablets to oral(0.36g/tablet,20 pieces of each plate,2 plate of each box,approval number: Z20080296),usage: take 4 tablets 3 times a day,take orally 30 minutes before the meal,1 month for a course of treatment,a total of three courses of treatment.The treatment group was treated with Manwei particless(10g/bag,6 bags of each box,sicuan medicine approval number: Z20080296),usage:take 10 g 3 times a day,boiling water,1 month for a course of treatment,a total of three courses of treatment.After the end of treatment.To compare the clinical efficacy of the two groups before and after treatment,especially the changes of PGI?PGII and PGR,and statistics and analysis the test results.Results:(1)After the end of the study,11 patients exit test because of different reasons.The remaining 69,including 34 in the control group and 35 in the treatment group.Comparing the comprehensive curative effect,the total effective rate of the control group after treatment was 67.65%,and the total effective rate of the treatment group was 88.57%.The total effective rate of the treatment group was significantly higher than that of the control group.The difference was statistically significant(p<0.05);(2)Comparing the average scores of each symptom,stomach bliges(or swelling pain),Poor appetite,acid reflux,belching,weak in the control group after treatment were 1.23±0.60,0.56±0.70,0.56±0.70,0.88±0.81,0.50± 0.66,and in the treatment group were 0.94±0.42,0.20±0.41,0.26±0.56,0.29±0.57,and 0.11 ± 0.32,in the control group were significantly higher than those in the treatmentgroup.After statistical analysis the difference was statistically significant(p<0.01);(3)Compared with gastroscopy,the total effective rate in the control group was 70.59%,and the total effective rate in the treatment group was 91.42%,the total effective rate of the treatment group was significantly higher than that of the control group.After statistical analysis,the difference was significant(p<0.05);(4)Compared with the pathological of atrophy,the total effective rate in the control group was 67.65%,and the total effective rate in the treatment group was 88.57%,the total effective rate of the treatment group was significantly higher than that of the control group.After statistical analysis,the difference was significant(p<0.05).There was no significant difference between the treatment group and the control group in improving the efficacy of gastric mucosal intestinal metaplasia and dysplasia.There was no significant difference between the treatment group and the control group(P>0.05).(5)For PGI,PGII and PGR,the average PGI of the control group before treatment was 51.15±12.06,after treatment,the mean PGI was 72.71±18.84,and the average PGR before treatment was 6.66±1.73,after treatment,the average PGR was 10.87±2.85.The average PGI of the treatment group before treatment was 49.23±10.25,after treatment,the mean PGI was 95.52±19.44,and the average PGR before treatment was 6.72±1.80,after treatment,the average PGR was 14.86±3.25 Both the PGI and PGR in the two groups were significantly higher than before treatment.Compared with the control group,the average values of PGI and PGR in the treatment group increased more significantly.After statistical analysis,the difference was significant.(P<0.01).Conclusion:The clinical curative effect of Manwei particless is obviously better than that of Weifuchun tablets.In particular,the improvement of serum PGI and PGR was significantly better than that of Weifuchun tablets.We believe that the therapeutic effect may be through affecting the changes of PGI and PGR levels in patients with chronic atrophic gastritis.