Study On The Correlation Between Rheumatic Immune Disease And Dry Eye And TCM Syndrome Type

Purpose:Dry eye refers to any cause that causes tear fluid quality,abnormal amount,tear film due to dynamic abnormality,resulting in decreased stability,accompanied by eye discomfort and(or)ocular surface damage of a variety of diseases.Clinical patients often accompanied by eye symptoms found non-organ-specific rheumatological disorders,including dry eye become one of the complications of rheumatoid immune disease often accompanies,this shows that the dry eye has close relations with rheumatoid immune disease.Rheumatoid immune diseases caused by uveitis,scleritis,retinopathy,optic neuropathy,etc have been known by everyone,the degree of ocular involvement is related to the severity of the systemic disease,and ocular surface disease caused by these diseases are often ignored by clinical doctor.Based on rheumatoid immune diseases and the research status of dry eye,the author conducted the study,age,gender,course of treatment in patients with rheumatoid immune disease?laboratory indexes?diseases?TCM syndrome and the correlation of dry eye,combine traditional Chinese and western medicine to provide objective basis.Methods:In December 2015 to August 2016 in nanjing university of Chinese medicine affiliated hospital of jiangsu province hospital diagnosed with li rheumatism lead of non-organ-specific rheumatological disorders,100 cases of hospitalized patients with as the research object,record the age,gender,course and laboratory indexes,diseases,according to its local and systemic symptoms,tongue coating pulse condition,four diagnostic parameter,syndrome differentiation type,respectively with dry eye tear secretion test(SIT),it appears rupture time(BUT),corneal light staining(FL),subjective symptoms were analyzed,and investigate the relationship between rheumatoid immune diseases and dry eye.SPSS 21 was used for statistical analysis.Results:(1)The proportion of dry eyes and non-dry eyes of rheumatic immune diseases was 9:1,and the prevalence rate was 90%.Patients with rheumatoid immune disease had high dry eyes.(2)Women with the disease incidence rate is higher than male patients 14 patients with male 28 eyes,female patients with 76 cases 86 eyes,began in men and women,women patients with dry eye severity over men,FL in dry eye index score,BUT,SIT:in female patients with dry eye FL score higher than male patients,BUT short in male patients,SIT less than male patients(P<0.05).(3)The age distribution of the dry eye disease was 41-64years old,and the disease tended to be middle-aged and old.The age of the patient was negatively correlated with BUT(P<0.05).(4)The mean duration of the disease was 7.70±6.930 years.FL and subjective symptoms were positively correlated with the course of disease(P<0.05).However,it was negatively correlated with the course of illness(P<0.05).There was no linear correlation between SIT and disease(P>0.05).(5)Cases of this topic collection types are:rheumatoid arthritis(RA),primary sjogren's syndrome(pSS),secondary drying syndrome(sSS),systemic lupus erythematosus(SLE)and other rheumatic autoimmune disease.PSS,sSS in FL score is better than other rheumatoid immune diseases(P<0.05),the heaviest sSS subjective symptom scores(P<0.05),pSS and SLE and RA SIT less than other non-organ-specific rheumatological disorders(P<0.05).(6)Subjective symptoms in patients with positive frequency from high to low in turn is:fatigue of 134 eyes(74.4%),blurred vision,there are 114 eyes(63.3%),dry eye in the more than 111 eyes(61.7%),secretion of 100 eyes(55.6%),foreign body sensation,there are 87 eyes(48.3%),redness of 82 eyes(45.6%),itchy eyes of 71 eyes(39.4%),the tears have 67 eyes(37.2%),photophobia,46 eyes(26.6%),the difficult to open since morning 43 eyes(23.9%),eye pain or burning sensation with 33 eyes(18.3%),blink frequently 29 eyes(16.1%).The subjective symptoms of most patients are visual fatigue,blurred vision,dry eyes,increased secretions,and foreign body sensation.(7)Laboratory related inflammation and immune index,positive can increase dry eye,including:SSA antibody resistance,anti SSB antibody and rheumatoid factor(RF),immunoglobulin G(IgG),immunoglobulin M(IgM),immunoglobulin A(IgA),antinuclear antibodies,ANA.(8)Rheumatoid immune disease caused by severe dry eye syndrome types,mainly the virtual factors:corneal fluorescein sodium dyeing heavier evidence type is mainly for the phlegm and blood stasis obstruction syndrome,deficiency and blood stasis resistance of liquid,liver and kidney deficiency syndrome;The short rupture time of tear film is mainly phlegm stasis syndrome,liver and kidney deficiency syndrome,qi and blood deficiency syndrome;The main syndromes of low tear flow are deficiency and blood stasis resistance of liquid,qi and blood deficiency syndrome and phlegm stasis syndrome.The symptoms of the subjective symptoms are the syndromes of hot poison,deficiency syndrome of liver and kidney,deficiency and blood stasis resistance of liquid.Conclusion:This study through the analysis of the correlation of rheumatoid immune diseases and dry eye,found high prevalence of dry eye patients with rheumatoid immune disease,patients with dry eye and rheumatoid immune disease severity positive related to gender,age,course of the disease,laboratory indicators,diseases,and TCM syndrome types:with middle-aged women non-organ-specific rheumatological disorders;Longer course of illness;Anti-ssa antibody positive;Anti-ssb antibody positive;The RF positive;IgG positive;IgM.IgA is positive;The ANA titer is higher;PSS disease;SSS disease;TCM syndromes with phlegm and stasis syndrome,Yin fluid deficiency and deficiency of blood stasis syndrome,liver and kidney deficiency syndrome,especially in the routine of dry eye examination,prevention of serious dry eyes,and timely treatment.