Study Of Rheumatoid Arthritis Associated Laboratory Indicators And TCM Syndrome Type

Objective:In this study we analyzed 136 cases of clinical data in patients with rheumatoid arthritis,and rheumatoid arthritis(RA) is discussed dialectical traditional Chinese medicine and the correlation between the general data and laboratory indicators. For objective study of rheumatoid arthritis (ra) of traditional Chinese medicine dialectical classification provides a reference basis.Methods:By adopting the method of prospective studies,.determined in accordance with the patient’s syndromes, published in 2010, "22 professional and 95 disease TCM clinical path" "Wangbi (rheumatoid arthritis) treatment program" in rheumatoid arthritis syndrome type method, and to develop rheumatoid arthritis patients Watchlist, Collect the patient’s general information, main symptoms and laboratory data. Before first observation analysis treatment of syndrome type distribution and TCM syndrome type and the relationship between the general data and laboratory indexes; Then the syndrome were treated with conventional medicine therapy, record after treatment in patients with laboratory data. After the final statistical analysis of treatment-related TCM Syndrome arid laboratory parameters, as well as the treatment of the syndrome before and after treatment, the outcome of the situation laboratory parameters.Results:1. The relationship between TCM syndrome type and general data: 136 patients aged between 18 years old to 70 years old, The youngest patient was 18 years old and the oldest 70 years old, The average age (51.60±8.95). Using analysis of variance in the age distribution of each card.type, and there was no statistically significant difference(P>0.05).37 cases of male patients, accounting for 27.2%, and female patients 99 cases, accounting for 72.8%. Using chi-square gender composition ratio between six card type, and there was no statistically significant difference (P>0.05).2. The type of distribution:Rheumatism stagnation syndrome in 26 cases, accounting for 19.1%; Cold dampness syndrome in 24 cases, accounting for 17.7%; Damp heat stagnation syndrome in 37 cases, accounting for 27.2%; 8 cases of phlegm and blood stasis syndrome, accounted for 5.9%; Syndrome of deficiency of Qi and blood in 20 cases of two, accounting for 14.7%; Liver and kidney deficiency syndrome in 21 cases, accounting for 15.4%.3. Relationship and laboratory indexes:(1) Relationship with CRP:Before treatment CRP values among various syndromes pairwise comparison heat blockage syndrome and other four syndromes difference was significant (P< 0.05), CRP values between the syndrome two groups 4 weeks after treatment, P>0.05, the difference was not statistically significant; Application of paired t test respectively for each card type CRP values within the group comparison before and after treatment, comparison of heat blockage syndrome group within P<0.05, the difference was statistically significant. The rest of the syndrome in the group difference was not statistically significant (P>0.05). (2)Relationship with ESR:Each card type between two groups before treatment is hot and humid card bizu ESR value is significantly higher than qi deficiency syndrome(P<0.05),Statistically significant. ESR heat blockage syndrome was significantly higher than the liver and kidney deficiency syndrome(P<0.05), Statistically significant. After four weeks of treatment comparison between various syndromes ESR value group, heat blockage syndrome and deficiency of both blood ESR value difference was statistically significant(P<0.05), Heat blockage syndrome liver and kidney deficiency syndrome and ESR values were statistically significant differences (P<0.05).(3) The relationship with RF: RF-positive rate for the syndrome RA patients were found between the two groups.Between the various syndromes groups (p> 0.05). RF positive rate distribution:Damp heat stagnation syndrome> Cold dampness syndrome> Rheumatism stagnation syndrome> Liver and kidney deficiency syndrome > Syndrome of deficiency of Qi and blood. Before treatment groups among syndromes heat blockage syndrome and deficiency of both qi difference was significant (P<0.05); After four weeks of treatment comparison between various syndromes RF setting group, blockageof blood deficiency syndrome and heat difference was significant (P<0.05). (4)HGB, PLT, RBC, WBC and the ratio of neutrophils (N%) relationship:Each card type platelet HGB,PLT, RBC of red blood cells, white blood cells in the WBC and neutrophils ratio (N%) there is no obvious difference of values, without statistical significance.Conclusion:1. Hot and damp heat syndrome type of syndrome is the most common type of rheumatoid arthritis, and the average age of deficiency syndrome in patients with rheumatoid arthritis than positive RA patients.2. The results of this study found, CRP values between groups only heat blockage syndrome was significantly higher than other syndromes, and within the syndrome before and after treatment group, heat blockage syndrome before and after treatment CRP values had significant difference. This may indicate heat blockage syndrome most serious inflammation in RA patients, CRP is more sensitive to heat blockage syndrome RA, more relevant.3. ESR, RF not only reflect the degree of disease activity, and prompted one of ESR, RF RA heat may be used as an objective indicator Syndrome Classification4. The syndrome was no significant difference in the HGB, PLT, RBC, WBC and N% of the value, indicating that the index is difficult to reflect the characteristics of RA syndromes.