The Research Of Professor You Songxin's Differentiation And Treatment Of Primary Liver Cancer Clinical Experience And Academic Thought

Research purposes:Professor You Songxin's clinical medical records as the research object,through data mining analysis and the study of medical records to discuss the clinical experience and syndrome differentiation regularity on treating primary liver cancer,system summarizes Professor You's academic thoughts on the treatment of primary liver cancer.Research methods:Screening the PLC cases from Professor You Songxin's clinical medical records from December 2006 to February 2018.1n accordance with the diagnostic and exclusion criteria,86 cases of medical records were included in the study and a new database was established.With the help of statistical analysis software,the paper analyzes the pathogenesis,therapy,prescription drugs and prescription compatibility.The frequency statistics,factor analysis,complex network core analysis,association rules and so on,combined with the man-machine and case study,objective to summarize the clinical experience and academic idea of Professor You Songxin on treating PLC.Research result:(1)General situation:86 cases were picked out in total which 68 are male and 18 are female.The average age is(56.41±12.19)years old.(2)Syndrome distribution:Involving a total of 109 kinds of symptoms,which the frequency is more than 5 times in order:anorexia(41),diarrhoea(38),yellow urine(23),insomnia(19),hypo-chondriac pain(18),loose stools(17),ventosity(17),lower limb swelling(15),cough(14),astriction(12),exhausted(12),marasmus(11),aurigo(9),ascites(8),dry mouth(7),white sputum(7),discomfort with stomaches(7),diarrhea(6),body itch(6),gingival hemorrhage(6),fever(5),abdominal pain(5),walking instability(5),canker sores(5),nocturia more(5),nausea(5).Involving a total of 29 kinds of tongue and pulse,the frequency of more than 10 times as follows:thready pulse(104),string-like pulse(70),Bobai tongue(55),Bohuang tongue(22),Boshao tongue(19),Boni tongue(16),greasy tongue(14).(3)Pathogenesis distribution:86 cases of medical records involved in the pathogenesis of 84 species,the more common pathogenesis are:liver and kidney deficiency(24),stagnation of damp-heat(20),liver collaterals blocked(10),liver-spleen disharmony(10),kidney deficiency and liver sthenia(10)and so on.Through the analysis of the pathogenesis of syndrome factors,in the total of 26 kinds of pathogenesis of syndrome factors,the top6 are:liver(87),kidney(49),damp(46),heat(38),spleen(35),Yin deficiency(31).(4)Therapy distribution:86 medical records involved in the therapies of 57 species,which the frequency is more than 15 times in order:Reinforcing kidney(48),Remove dampness(45),Nourishing liver(39),Clearing heat(38).Nourishing yin(31).Invigorating spleen(24),Clearing liver(24),Softing collaterals(17).(5)The distribution of commonly used herbs:There are 272 herbs in the medical record in all,according to the frequency in turn from high to low the top10:Black soybean(70),Herba Hedyotis(66),Artemisia capillaris(64),Radix achyranthis bidentatae(62),baked licorice(62),Broussonetia paperifera fruits(59),Alisma(57),Fructus Liquidambaris(55),Zeeland(55),Malt(52).(6)The herbs factor analysis:It reflect the different combinations of drugs.Factor 1 of the herb consists of:Radix achyranthis bidentatae,Black soybean,Fructus Liquidambaris,Zeeland,Alisma,Broussonetia paperifera fruits;Factor 5 of the herb consists of:Oldenlandia diffusa,Spora Lygodii,Chicken's Gizzard-membrane.(7)The complex network core analysis:According to the results showed the usual prescript-tions are:Lan Dou Feng Chu Decoction,Fu Yue Huo Xue Decoction,Shenling baishu powder,Long Dan Xie Gan Decoction,Hua Gan Jian,Five Peels Decoction,Hao Qin Qing Dan Decoction,Ping Wei Powder,Xiao Yao Powder,Xi Jiao Di Huang Decoction etc.(8)Association rules results:Through the association rules analysis of the relationship between the symptoms,pattern of syndrome with drugs,such as anorexia with the drugs are Chicken's Gizzard-membrane,Zizyphus,Fried atractylodes,liver collaterals blocked with the drugs are toosendan fruit,rhizoma corydalis.Analysis conclusion:(1)Professor You proposed "stagnation of damp-heat,liver collaterals blocked,Uiver and kidney deficiency" is the basic pathogenesis of primary liver cancer,treat PLC around the basic pathogenesis,because the pathogenesis established treatment and the complex prescription.Eliminating pathogenic is in preference to strengthening the body resistance in the treatment.(2)Professor You thinks the pathological nature is much the root is empty and the surface is real,deficiency syndrome and empirical inclusion.The main pathological factors are dampness,heat,phlegm,retained morbid fluid is the auxiliary pathological,often and folders or composite.The disease location is mainly in the liver,with the spleen and kidney is closely related.involving stomach,lung and heart,often multi viscera disease.(3)Professor You treat the primary liver cancer common treatment is to nourishing yin and clearing heat,invigorating spleen and dissipating dampness,reinforcing kidney and nourishing liver,clearing liver and softing collaterals.The nourishing yin often choose:Radix Ophiopo-gonis,Radix adenophorae,Raw radix rehmanniae.The clearing heat often choose:Oldenlandia diffusa,Giant knotweed,Scutellaria baicalensis.The invigorating spleen often choose:Fried atractylodes,Poria cocos,Malt The dissipating dampness often choose:Lygodium japoni-cum,Alisma,Fructus Liquidambaris.The reinforcing kidney often choose:Black soybean,Broussonetia paperifera fruits,Prepared rehmannia root The nourishing liver often choose:Medicinal Cyathula Root,Broussonetia paperifera fruits,Radix Rehmanniae Recens.The softing collaterals often choose:Raw radix rehmanniae,Cortex moutan,Dry chinaberry fruit.(4)Professor You Songxin treat the primary liver cancer in common prescription:Lan Dou Feng Chu Decoction,Fu Yue Huo Xue Decoction,Shenling baishu Pow-der,Long Dan Xie Gan Decoction,Hua Gan Jian,Five Peels Decoction,Hao Qin Qing Dan Decoction,treatment by the common prescriptions,with the pathogenesis of primary(16)or the main symptoms(5)of addition and subtraction.(5)Besides,the research also found that other experiences of Professor You in treating primary liver cancer:?Make good use of antitumor drugs;?Less use of insects drugs;?Make good use of small preparations;?Prefer to use the Chinese herbal medicine of LingNan.