Correlation Between Serum 25-hydroxyvitamin D And Serum NGAL And Diabetic Nephropathy And TCM Syndrome Types

Objective:By comParing the levels of serum 25-hydroxyl-D and serum NGAL in healthy adults and Patients with diabetic nePhroPathy without Proteinuria,the correlation between diabeticnePhroPathy and the distribution of TCM syndromes was explored.Methods:Collect 90 diabetic kidney disease(DKD)and 30 healthy adults as control grouP(NC),according to the urinary albumin/creatinine ratio(UACR)will DKD grouPed into Patients with normal albuminuria grouP(NA),trace albuminuria grouP(MA),a large number of albuminuria grouP(CA),research objects are collected the age,course of the disease,gender,blood Pressure,neutroPhils gelatinases related aPoliPoProtein(NGAL),25(OH)D3,fasting Plasma glucose(FPG),blood sugar 2 hours after meal(2 HPG),glycosylated hemoglobin(HBA1C),serum creatinine(SCR),glomerular filter(e GFR),total cholesterol(TC),triglyceride(TG),TCM symPtoms such as index.result:1.In the NC grouP,the NA grouP,the MA grouP and the CA grouP,the decrease was significant,and the difference was statistically significant comPared with the control grouP(P<0.05).NA was higher than MA grouP and CA grouP,and the difference was statistically significant(P<0.05).The MA grouP was higher than the CA grouP,and the difference was statistically significant(P<0.05).2.In the NC grouP,NA grouP,MA grouP,and CA grouP,the serum NGAL showed an ascending trend,which was statistically significant comPared with the controlgrouP(P<0.05).The NA grouP was lower than MA grouP and CA grouP,and the difference was statistically significant(P<0.05).The MA grouP was lower than the CA grouP,and the difference was statistically significant(P<0.05).3.25(OH)D3 and course 3.25(r = 0.242),SBP(r = 0.677),DBP(r = 0.449),TG(r = 0.264),TC(r = 0.214),FPG(r = 0.540),2 HPG(r = 0.646)and SCR(r =0.302),UACR negative correlation(r = 0.813)(P<0.05),whereas and eGFR(r = 0.691)were positively correlated(P<0.05),and through multiple stepwise regression analysis it is concluded that eGFR as independent variables,25(OH)D3 as the dePendent variable regression equation is:Y = 50.93 + 0.167 X(r = 0.474,P<0,01);Serum NGAL and duration(r = 0.224),SBP,DBP(r = 0.657)(r = 0.432),TG(r = 0.296),the FPG,2 HPG(r = 0.482)(r = 0.671)SCR(r = 0.412),UACR was a Positive correlation(r = 0.923)(P<0.05),while with eGFR negative correlation(r = 0.789)(P<0.05),and through multiple stePwise regression analysis it is concluded that eGFR as independent variables,NGAL as the dependent variable regression equation is:Y=24.519 2.356 X(r = 0.581,P<0,01).4.There were 22 cases(73.4%)in the NA grouP,5 cases(16.6%)of qi Yin deficiency syndrome(16.6%),Yin and Yang deficiency,and three cases(10%)of blood stasis.In the MA group,there were 17 cases(56.7%),9 cases(30%)of qi and Yin de ficiency,two deficiency of Yin and Yang,and four cases(13.3%)of blood stasis.The re were 6 cases(20%),18 cases(60%),Yin and Yang deficiency,and 6 cases(20%)of blood stasis.The distribution of TCM syndromes in each group was significantly different(P<0.001).25(OH)D3 in TCM syndrome type from Yin deficiency heat to qi and Yin deficiency syndrome and Yin and Yang are two deficiency,blood stasis in the Process of the change of water stop card,its level is,in turn,is gradually declining,Yin deficiency syndrome of 25(OH)D3 hotness than qi and Yin deficiency syndrome,Yin and Yang are two deficiency,blood stasis water stop,statistically significant difference(P<0.05),qi and Yin two study of 25(OH)D3 than two deficiency of Yin and Yang,blood stasis water stoP is high,but there was no statistically significant difference between grouPs(P>0.05);Serum NGAL in Yin deficiency syndrome and hotness and Yin deficiency syndrome,Yin and Yang are two deficiency,blood stasis water Park is a trend of increase one,Yin deficiency syndrome of NGAL hotness with qi and Yin deficiency syndrome,Yin and Yang are two deficiency,blood stasis water to stoP the NGAL,clear difference was statistically significant(P<0.05);The NGAL in the blood stasis water stop syndrome was higher than the deficiency of qi Yin and Yin,but there was no statistically significant difference between the two groups(P<0.05).Conclusion:(1)25(OH)D3 and NGAL can reflect the changes of renal function in DKD Patients to a certain extent,and whether it is exPected to be an effective indicator to evaluate early DKD still needs further study and discussion.(2)DKD TCM syndromes from Yin deficiency and heat to deficiency of qi and Yin and Yin and Yang,and the evolution Process of blood stasis water stoP syndrome(OH)D3 decreased in turn;And NGAL goes uP in turn.How to establish the exact relationshiP between 25(OH)D3,NGAL and DKD TCM syndrome is worth further discussion.