The Clinical Research Of Influence About Safflower Injection On D-dimer And Fibrinogen Of Active Rheumatoid Arthritis

Objective: This study designed to evaluate the clinical effect and the influence on D-dimer(DD)and fibrinogen(FIB)of Safflower Injection in treatment of active rheumatoid arthritis(RA).And to investigate the therapeutic effect on RA and the influence on blood flow of RA patients.To provide a new perspective for the treatment of RA and a basis for the prevention and treatment of cardiovascular and cerebrovascular diseases(CCVD).Methods: 60 patients which from rheumatism disease outpatient and ward of Henan province hospital of Traditional Chinese Medicine met the criteria in accordance with active RA patients were randomly divided into control and test groups,30 cases in each.The control group using methotrexate(MTX)and loxoprofen sodium tablets as the therapeutic drug.Experimental group was given Safflower Injection in the control group basis.Continuous treatment for 15 days.Observe the number of joint swelling and joint pain,morning stiffness time and detect erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),Interleukin-1(IL-1),DD,FIB of the two groups' patients respectively before and after treatment.Use SPSS l9.0 application software for data analysis and comparison of efficacy between the two groups.Results: 1.The overall efficacy rate of the test group was 89.7%,and the control group was 72.4%.The difference was statistically significant(P<0.05),the test group was better than the control group.2.After treatment,the DAS28 score of the two groups was lower than before treatment,the difference was statistically significant(P < 0.05);And the DAS28 score of the two groups were compared after treatment,the difference was statistically significant(P < 0.05);the test group was better than the control group.3.After treatment,the ESR,CRP,IL-1 values of the two groups was lower than before treatment,the difference was statistically significant(P < 0.05);and the two groups were compared,the difference was statistically significant(P < 0.05);the test group was better than the control group.4.After treatment,the DD,FIB values of the two groups was lower than befo re treatment,the difference was statistically significant(P < 0.05);and the two groups were compared,the difference was statistically significant(P < 0.05);the test group was better than the control group.Conclusion: Safflower injection combined with MTX,loxoprofen sodium tablets can effectively improve the clinical symptoms and inflammatory markers in patients with active RA.At the same time,it can reduce the values of DD and FIB,and better than MTX,loxoprofen sodium tablets alone.At the same time,this method plays a certain role in the prevention and treatment of CCVD in patients with RA.