Evaluation Of TGF-β1 +869T/C Gene Polymorphism And Essential Hypertension And Preeclampsia Risk:A Meta-analysis

Objective:To systematically evaluate the associations between transforming growth factor beta-1(TGF-β1)+869T/C gene polymorphism and the genetic susceptibilities of essential hypertension(EH)and preeclampsia(PE).Materials and Methods:We searched PubMed,MEDLINE,Web of Science,Cochrane Library,China National Knowledge Infrastructure(CNKI),China Biological Medicine Database(CBMD),Wan fang database and VIP datebase by using "transforming growth factor/TGF,genetic polymorphism,hypertension/blood pressure/preeclampsia" as keywords.The case-control or cohort study of the TGF-β1 +869T/C gene polymorphism and EH,PE genetic susceptibility was collected.The search time was set from the beginning of database built to November 30,2016,and no limitation for language.After the literatures were screened rigorously according to inclusion and exclusion criteria,the data extracting and quality review were performed by 2 reviewers independently.The current meta-analysis was conducted by using Stata 12.0 and Review manager 5.3 softwares.Results:18 case-control studies(3247 EH patients and 3517 controls)and(591 PE patients and 706 controls)were identified.There was a significant association between TGF-β1 +869T/C gene polymorphism and EH,PE.The pooled OR for the frequency of C allele in EH was 1.57,95%CI:1.35-1.83,P=8.41×10-9.The pooled OR for CC/TC+TT genotype was 2.09,95%CI:1.50-2.91,P=1.19×10-5 and for TT/TC+ CC genotype was 0.64,95%CI:0.54-0.75,P=1.16×10-7.Subgroup analysis showed that The pooled OR for the frequency of C allele in Chinese EH population was 1.71,95%CI:1.47-1.99,P = 2.56 × 10-12;CC genotype OR was 2.67,95%CI:1.91-3.74,P = 8.41 × 10-9;TT genotype OR was 0.63,95%Cl:0.54-0.73,P = 1.74 ×10-9.The pooled OR for the frequency of C allele in non-Chinese EH population was 1.27,95%CI:1.09-1.49,P=0.002;CC genotype OR was 1.20,95%CI:0.98-1.46,P=0.07;TT genotype OR was 0.63,95%CI:0.38-1.04,P=0.07.The pooled OR for the frequency of C allele in PE was 1.23,95%CI:1.05-1.43,P=0.011,for CC/TC+TT genotype was 1.49,95%CI:0.87-2.56,P=0.15 and for TT/TC+ CC genotype was 0.55,95%CI:0.31-0.96,P=0.03.The Begg’s and Egger’s test suggested no significant publication bias.Sensitivity analysis showed that the result is stable.Conclusion:1.The current meta-analysis suggested that C allele and CC genotype of TGF-β1+869T/C gene polymorphism might be related to the increased risk of EH,especially in Chinese population,whereas TT genotype is a protective factor.2.C allele of TGF-β1+869T/C gene polymorphism may increase the risk of PE and TT genotype has a protective effect.