The Relationship Between Initial Treatments And Motor Complications In Patients With Parkinson's Disease

Objective: To investigate the relationship between initial treatments and motor complications in patients with Parkinson's Disease(PD).Methods: Between December 2014 to December 2015,we enrolled 222 PD patients in the PD clinic of our hospital.We assessed all the patients in the information of basic demographics,age of onset,course,motor manifestations,initial and present treatments and motor complications.Results: In the total of 222 patients with PD in this study,121 patients complained motor fluctuations(54.5%)and 44 patients suffered dyskinesia(19.8%),and both of them were 42 patients(18.9%).There was significant difference in the incidence of motor fluctuations between amantadine group(71.9%)and non-amantadine group(51.6%)(P<0.05),including motor and non-motor symptoms fluctuations,especially in bradykinesia,atony,flexibility and thought slowness(P<0.05).We also found the significant difference in the incidence of sweating between the dopamine agonists group(3.0%)and the non-dopamine agonists group(18%)(P<0.05).Patients initially treated with dopamine agonists had lower scores in dyskinesia,subjective assessment,objective assessment and Unified Dyskinesia Rating Scale assessment(P<0.05).PD course and daily levodopa dosage were the independent factors for motor fluctuations and dyskinesia.Conclusions: Starting treatment with amantadine cannot decrease the incidence of motor fluctuations.However,patients initially treated with dopamine agonists improve motor fluctuations and dyskinesia.