Short-term Predictive Value Of Serum Ngal Levels In Chronic Heart Failure Patients With Renal Function Injury

objective1.To explore short-term predictive value of serum neutrophil gelatinase-associated lipocalin(NGAL)in chronic heart failure patients with renal function injury?2.To assess the relationship between serum neutrophil gelatinase-associated lipocalin levels and worsening renal function in patients with chronic heart failure.MethodWe studied 116 patients with chronic heart failure who hospitalized in cardiovascular medicine between January 2016 to June 2016.First,rule out congenital heart disease,rheumatic heart disease and senile valvular heart disease,basic kidney disease and hospitalization time,not less than one week.By detecting the serum NGAL and serum creatinine at admission,day 3and discharge day.Calculate glomerular filtration rate according to Cockcroft-Gault formulat.The levels of serum NGAL were measured by latex turbidimetric immunoassay.Patients were devide into two groups according to NGAL criteria at admission,NGAL elevated group 69 cases and 47 cases of normal.Compare the two groups about the decline of the glomerular filtration rate after admission.The leavels of glomerular filtration rate at admission,at day 3 and at the day of discharge were compared between two groups.Compare the positive rate of abnormal renal function between the two groups by Chi-square test.Analyse the correlation about serum NGAL?glomerular filtration rate and serum creatinine.Result1.General index comparison between the two groups,NGAL normal group and higher NGAL height,weight,age difference is not significant,P > 0.05;EF and BNP difference was statistically significant between the two groups,P < 0.05.2.NGAL rise and NGAL normal group glomerular filtration rate decline after admission has significant difference,P < 0.001.3.The NGAL normal group,third day admission,discharge the glomerular filtration rate are lower than on the day of admission glomerular filtration rate,P >0.05;Discharged from hospital on the same day compared with 3 days after admission glomerular filtration rate,P > 0.05.4.Elevated serum NGAL group,third day admission,discharge the glomerular filtration rate are lower than on the day of admission glomerular filtration rate,P <0.001;Discharged from hospital on the same day with 3 days after admission,glomerular filtration rate(P < 0.01).5.On the day of admission on the same day,3 days after admission,discharge,NGAL normal group of glomerular filtration rate compared with higher NGAL group of glomerular filtration rate,the difference was statistically significant,P < 0.01.6..NGAL rise group 3 days after admission and discharge the positive rate is higher than NGAL abnormal renal function normal group,P < 0.001.7.The serum level of NGAL positively correlated with serum creatinine,serum level of NGAL and negatively correlated with glomerular filtration rate,P < 0.001.ConclusionThis study suggests the serum neutrophil enzyme related lipid carrier protein gelatin(NGAL)can be used as the early prediction of chronic heart failure with renal injury sensitive indicator;2.This study suggests the serum neutrophil enzyme related lipid carrier protein gelatin(NGAL)can be used for the evaluation of chronic heart failure with the severity of the deterioration of renal function in patients with renal function injury;3.Dynamic monitoring the change of serum NGAL,can provide the changes of heart kidney syndrome,reference serum level of NGAL,choosing the appropriate intervention measures,to improve the overall prognosis of heart kidney syndrome has certain help.