Volumetric Changes In The Upper Airway After Orthodontic-orthoganthic Surgery For Skeletal Class Ⅲ Malocclusion:a Meta Analysis

Objective:To evaluate volumetric changes in the upper airway after orthodontic-bimaxillary surgery for skeletal class Ⅲ malocclusion by meta-analysis,and to provide reference for the selection of surgical operation for skeletal class Ⅲ malocclusion.Method:Studies about volumetric changes in the upper airway after orthodonticbimaxillary surgery for skeletal class Ⅲ malocclusion were Searched from the English database(Cochrane library,Embase,Pub Med,Web of Science)and Chinese database(Wangfang,VIP,CBM,CNKI).What’s more,we search the Chinese Journal of Orthodontics and the Chinese Journal of Evidence-Based Medicine by hand.All the literatures included were evaluated using the Newcastle-Ottawa Scale(NOS)and were analyzed by RevMan 5.3.Result:Nine literatures were included in total and 204 cases about volumetric changes in the upper airway after orthodontic-bimaxillary surgery for skeletal Ⅲ malocclusion were counted in.Among them,there were six literatures involved in nasopharyngeal volume,eight literatures involved in oropharyngeal volume and seven literatures involved in total volume(sum of nasopharyngeal volume and oropharyngeal volume).The results of the meta-analysis were as follows:1.There was no statistical difference about nasopharyngeal volume change(WMD=0.04cm3,95%CI[-0.35,0.42],P>0.05),and homogeneity was good(I2=0,P=0.84).2.There was statistically significant difference about oropharyngeal volume change(WMD=-2.24cm3,95%CI[-3.25,-1.23],P<0.05),and heterogeneity was low(I2=22%,P=0.26).3.There was no statistical difference about total volume change(WMD=-1.03 cm3,95%CI[-2.28,0.22],P>0.05),and homogeneity was good(I2=0,P=1.00).Conclusion:1.There were no changes about nasopharyngeal volume and total volume,while there was decrease about oropharyngeal volume after orthodontic-bimaxillary surgery for skeletal class Ⅲ malocclusion.2.It might be better to consider orthodontic-bimaxillary surgery for skeletal class Ⅲ malocclusion with certain risk factors about OSAHS,but there was still a risk of airway narrow after orthodontic-bimaxillary surgery for skeletal class Ⅲ malocclusion.