Clinical Study Of Treatment For Diabetic Osteoporosis With QiXianGu Heji

Objective:To evaluate QiXianGu Heji's clinical efficacy and safety in the treatment of diabetic osteoporotic patients with the Chinese Medicine Syndrome Score,bone mineral density(BMD),biochemical markers of bone turnover,blood glucose,hemorheology,and blood lipid levels as the end result indexes.Methods: 70 patients were recruited during June,2015 to March,2016 for treatment at the Medical University affiliated hospital.Recruitment criteria was in line with the hospital admission diagnostic criteria.Patients were single-blinded randomly assigned into treatment group and control group with 35 patients in each group.Gushukang capsule was given to the control group and QiXianGu Heji was given to the treatment group continuously for 180 days as treatment.All indexes were measured before and after the treatment for both groups.Statistical software SPSS 19.0 was used in data analysis.Results:1.There were no significant difference(P>0.05)in the demographic data between two groups.The effective rates were 65.71% and 88.67% for control group and the treatment group respectively with a statistical significant difference(P<0.05).Therefore,the clinical effectiveness of Qi XianGu Heji is better than Gushukang capsule.2.Both groups showed a significant decrease(P<0.05)in Traditional Chinese Medicine Syndrome Score after treatment.And this decrease was significantly different between 2groups(P<0.05)which again,indicated that QiXianGu Heji is better in improving the clinical symptoms than Gushukang capsule.3.Both groups showed an increase in the bone mineral density(BMD)after the treatment.But in the comparison between two groups,the increase in the treatment group wasstatistically significantly higher(P<0.05).Therefore,the treatment group is more effective in increasing the bone mineral density.4.After treatment,the hemorheology indexes,total cholesterol,triglyceride and low density lipoprotein were decreased in both groups;but the treatment group had a better curative effect than the control group(P<0.05).5.There was no report of adverse reaction or event during the clinical trial.There was also no significant change in the safety index during the course of treatment.Conclusion:QiXianGu Heji can significantly improve the clinical symptoms,bone mineral density,and lipid metabolism in the treatment of diabetic osteoporotic patients.Its' lack of adverse reactions profile also proven QiXianGu Heji is a safe and effective treatment option for these patients.