Clinical Curative Effect Of Huatantongsui Decoction Combined With Rehabilitation Training On Phlegm Obstruction Type Hemiplegic Stroke Patients

Objective: To observe the clinical effect of Huatantongsui Decoction on phlegm obstruction type stroke patients,which were treated as the research objects in this study,then to analyze the possible mechanism of Huatan Decoction.Methods: The phlegm obstruction type stroke patients 120 cases met the inclusion criteria were selected in the rehabilitation medicine department of Yiling hospital,who were randomly and equally divided into the control group and the treatment group by the medical record number.The whole patients were treated with the basic treatment like anti-platelet aggregation,lowering blood pressure,lowering blood glucose,and so on.On the basis of basic treatment,the rehabilitation therapy like Brunnstrom,Bobath,motor relearning,and so on were applied to improve the upper and lower limb movement,life ability,balance ability and so on.The control group was treated with the basic and rehabilitation therapy;but the treatment group was treated with Huatantongsui Decoction on the basis of the control group,1 agent / day,sooner or later each time.Before and after treating,the upper and lower limb function,exercise ability,life ability,and so on were evaluated by the simplified and different rating scales like Brunnstrom,Fugl-Meyer,Ashworth,ADL and Berg.The clinical symptoms were evaluated by the Criterion of Diagnosis and Therapeutic Effect of Apoplexy.The content of serum cholesterol and triglyceride,the characteristics of Hemorheology including the whole blood viscosity,fibrinogen and plasma viscosity,serum levels of inflammatory factors IL-6,IL-1β and tumor necrosis factor TNF-α were tested.The data were analyzed by SPSS17.0 statistical software,the count data were tested by X2 test,the measurement data were tested by T test,and the ranked data were analyzed by Ridit test,P <0.05 as the significant difference.Results:1 Comparison of basic information between two groupsThe basic information like sex,age,duration of disease and so on had no statistical significance(P>0.05).2 Comparison of clinical symptom scores between two groupsAfter treating,the clinical effective rate of the treatment was up to 93.22%,which was significantly higher than that of the control group 78.94%(P<0.05).After treating,the clinical symptoms of two groups were all significantly improved(P<0.05).The comparison of clinical symptoms between the two groups had no statistical significance(P>0.05).3 Comparison of Brunnstrom scale scores,Fugl-Meyer scale scores,sport ability scores and life ability scores between two groupsAfter treating,there were significant differences between the two groups in the scores of upper limb and lower limb function,motor function,balance ability and life ability than that before treating(P<0.05).After treating,the comparison of the score indexes between two groups had statistical significance(P<0.05).4 Comparison of hemorrheological parameters between two groupsThere were not significant difference in the hemorrheological parameters of the control group between before and after treating(P<0.05).After treating,the characteristics of Hemorheology including whole blood viscosity,plasma viscosity and fibrinogen in treatment group were lower than that before treating(P<0.05).The hemorrheological parameters of the treatment group were significantly reduced than the control group(P<0.05).5 Comparison of the levels of serum TC and TG between two groupsAfter treating,the serum triglyceride levels in two groups were significantly lower than those before treating,the difference was statistically significant(P<0.05),and there were statistically significant in comparison between groups after treating(P<0.05).6 Comparison of the levels of serum IL-6,IL-1β and TNF-α between two groupsThere were not significantly different in the serum levels of IL-6,IL-1β and TNF-α of the control group between that before and after treating(P<0.05).After treating,the serum levels of IL-6,IL-1β and TNF-α in the treatment group were significantly lower than that before treating(P<0.05).And after treating,the serum levels of IL-6,IL-1β and TNF-α in the treatment group were significantly lower than that in the control group(P<0.05).Conclusions:1 Huatan tongsui Decoction based on the principle of eliminating phlegm for resuscitation and Promoting Blood Circulation with rehabilitation therapy can significantly improve clinical symptoms,the hemiplegic limb function,motor function,balance ability and the ability of living independently,and improve the quality of life of patients,which has shown good therapeutic effect on phlegm obstruction type stroke patients.2 The mechanism of Huatan tongsui Decoction on phlegm obstruction type stroke patients was studied deeply.The result may be closely related to lowering the level of blood lipid,inhibiting inflammatory factors and improving hemorheology.