Analysis Report Of Anti-infective Agents Adverse Drug Reaction Occurred In 2012-2014,and Factors Affecting In Hebei Provincial

Objective: Adverse drug reactions(ADR)refers to eligible obtains areas under normal ueage and dosage of has nothing to do with the purpose of harmful response.Although our country's adverse reaction system was set up late,but at present our country adverse drug reaction monitoring system has been gradually perfected.In 2012 hebei province adverse drug monitoring system basic establishment,in the adverse drug reactions report collection has made great progress.Hebei province adverse drug reaction reports that the county level coverage rate reached 100%,the number has reached 42586 parts,per million population average number of adverse reactions reports reached592.7 parts.In accordance with the world health organization recommended amount Word Health Organization.Data shows,The adverse drug reactions report of anti-infective agents adverse drug reaction has more,especially the antibiotic adverse reactions.This study aims to analysis of anti-infection of adverse drug reactions happen in Hebei province in 2012-2014,analysis patient factors,regional factors and drugs is equal to the relationship between the occurrence of adverse reactions.The report summary the application of the anti-infective drugs in the province of the hospital,summarize the application of hospital infection and drug resistance in the province,in order to reduce the incidence of adverse drug reactions.Method: Gather the data of 2012-2014 medical institutions reported of anti-infection adverse drug reaction,in order to analyse the data of patients with gender,age,severity,time distribution,hospital level,drug classification descriptive etc.Use the Microsoft Excel software(Microsoft Excel 2010)to review and sort out the data.The data was analyzed by condition Logistic regression,and the OR value and 95% confidence limit were calculated.Results: In 2012-2014,Hebei province received 33434 cases reports ofanti-infection adverse drug reaction(14546 in male and 15332 in female),740 cases of serious(0.02%),serious cases ascending trend year by year.Tertiary medical institutions in Hebei province reported serious adverse drug reactions report the most.About rate of adverse reaction report,Baoding city was significantly higher than other areas.Method in province of anti-infective drug adverse reaction cases,most of them with antibiotics and chemical synthesis of antibacterial drug class as the main components.The number of injection dosage forms cause of adverse reaction is more than Oral dosage forms.Univariate analysis indicated that the occurrence of adverse reaction relate to the patient's age,weight,history of adverse drug reaction,smoking history,drug classification,grade of dosing way,hospitals and regional.The result of condition logistic regression multivariable analysis indicated that age,history of adverse drug reaction,drug classification,grade of dosing way,hospitals,and regional are the adverse drug reactions risk factors.The highest ADR rate was found in gerontal group.Patients who had history of adverse reactions are more likely had ADR.Antibiotics of antibacterial drug(OR=0.236),injection dosage(OR=0.556),tertiary medical institutions(OR=0.928)and economic developed city(OR=0.471)are more likely had ADR.Conclusions:1 Medical workers should be paid attention to in the use of antibiotics:1.1 Treatment of elderly patients and patients with history of adverse drug reactions should be more careful,cautious.The elderly has more basic diseases,the phenomenon of long-term oral drugs,drug clinical medical personnel for the elderly should be cautious,considering the combination of adverse drug reactions,adhere to the principle of rational use of drugs,achieve individualized dosage,so as to reduce the incidence of adverse drug reactions.1.2 According to the condition to choose the appropriate method,clinical treatment can oral medicine to achieve,in principle,as far as possible not to choose the drug injections.2 Grassroots medical institutions should strengthen the importance of adverse drug reactions,according to the adverse drug reaction report and monitoring measures for the administration of active reporting adverse drug reactions reports.