Qingdao Area Investigation And Trend Analysis Of Adverse Drug Reactions

Object:To investigate the features of ADRs in Qingdao and to give advice on the safe use of medications, we collect information of ADR reports during2006to2010in Qingdao and analyze it retrospectively.Methods:According to the ADR term sets and ADR report regulation, we analyze the ADR reports collected during2006to2010with phamacoepidemiological methods. With the help of EXCEL and manual screening, retrospective statistics including the amount of ADR reports, gender, age, previous ADR history of the patients, type of ADR, organ/organization affected, medication, dosage forms, drug delivery, and the result of the ADR. Detailed analysis is conducted during the serious ADR reports. Items of the ADR reports are verified before the analyses.Results:During the31708ADR reports, the male/female proportion is1.28, occurred most in18-40,41-65years people. ADRs occurred most in gastrointestinal system, skin and appendages damages and body as a whole-general disorders. Anti-infective, central nervous system(CNS) and cardiovascular drugs caused most ADRs. Fluoroquinolones, macrolide antibiotics and cephalosporins are anti-infective that ADRs occurred most frequently. In CNS drugs, most ADRs are caused by anti-inflammatory drugs, CNS stimulates and drugs for cerebrovascular diseases. In cardiovascular system drugs, anti-angina drugs, antihypertensive drugs and calcium channel blockers cause most ADRs. In addition, ADRs caused by antibiotic compounds are increasing in recent years, which should be vigil anted in clinical therapy. Analysis finds that antitumor agents, CNS and cardiovascular drugs caused most serious ADRs, and ADRs mainly occurred in body as a whole-general disorders, skin and appendages damages. Medications causing serious ADRs are docetaxel, gemcitabine, cisplatin, azithromycin, levofloxacin,etc.Conclusion:ADR factor should be taken full account of in the clinical use of drugs, we should try to choose dosage forms and drug delivery causing fewer the adverse reactions under the premise of ensuring the efficacy. Rational dosing regimens should be developed according to the characteristics of the drug to prevent and reduce the incidence of ADRs. The patients should be closely observed during the medication course so that timely treatment can be implemented when an adverse reaction happens. In addition, the ADR monitoring report system has been matured in the past few years, but there are still inadequates. By strengthening the supervision and collection of ADR cases and fully analyzing can make a great significance to the promotion of safety and rational clinical use of medicines.