Analysis Of Adverse Reaction Of Anti-tumor Drugs From 2013 To 2016 In A Prefecture-level City

Objective The purpose of this study was to investigate the related factors of adverse reactions caused by anti-neoplastics and discuss the effects of related factors,including sex,age,chemotherapy regimens,antineoplastic drugs,drug delivery,prevention and treatment on the adverse reactions,which provide a reference for rational clinical drug use,aiming to increase the therapeutic effect and reduce the adverse reaction,and to improve both the quality of life and the cure rate of patients ultimately.Methods Ecollect 1500 cases of anti-tumor drug adverse reactions report data from a food and drug administration,and retrospectively analyze most kinds of adverse reactions due to the use of antineoplastic drugs in cancer patients and the influence of related potential factors.Results 1.1500 cases of anti-tumor drug adverse reactions were reported.Overall,there were 679 males and 821 females,and the media age was 59 years(rang 3~89)2.The most common adverse reactions to antineoplastic drugs were the digestive system reactions.1~4 levels of the incidence of nausea and vomiting gastrointestinal adverse reactions accounted for 55.4%,20.5%,20.4% and 20.5%,respectively.As the growth of the age,3~4 levels of the incidence of nausea and vomiting was increase,but was reduce of the more than 70 years old patients.Upregulation level of nausea and vomiting was significantly associated with sex(P<0.001).3.As the age increases,the incidence of bone marrow suppression reduce,the I~IV degrees of bone marrow inhibition rates were 13.5%,15.5%,3.9% and 15.5%,respectively.The incidence of myelosuppression in male patients was significantly higher than that of female.However,there was no significant difference between the sex and the extent of myelosuppression.4.In the combination of drugs,FOLFOX regimen,GP regimen and TP regimen were most frequently used,with 86.2% and 86% of the digestive tract reactions of the FOLFOX regimen and TP regimen,respectively,higher than the GP regimen(71.8%).The maximum incidence of bone marrow suppression in TP was 82.1%,while FOLFOX scheme and GP regimen were 42.2% and 45% respectively.5.According to the different types of anti-cancer drugs,the corresponding adverse reactions were also different.6.The use of chemotherapy drugs was easy to cause infection and should be paid attention to it.7.Serotonin antagonists had significantly reduced the incidence of III~IV levels nausea and vomiting in the process of cancer chemotherapy in patients,which have become the drug of top choice for preventing nausea and vomiting during chemotherapy or surgery.8.Most reports of adverse reactions were reported by nurses and doctors in tertiary hospitals,and the description of the evaluation of the results interm of the report was “very likely”.But,most of the results in adverse reactions were described as ‘healing' and ‘improvement',and these reports showed that the incidence of adverse reactions in intravenous drip was significantly higher than other routes,such as oral administration and intramuscular injection.