Study On Serum Epidemiology Of Pertussis And Diphtheria

Objectives: Analyzing antibody level of pertussis and diphtheria in newborns and community health crowd in order to provide the scientific basis for the adjustment of vaccination strategies based on background of pertussis reappearance.tire levels,tire antibody nagative turn rate,antibody positive rate and antibody levels of community people monitoring,the binhai new area and even the pertussis reappearance of pertussis vaccination strategies against the Background of adjustment provided the scientific basis.Methods: A total of 132 newborns were recruited and their cord blood specimen were collected at birth for detecting fetal transmission antibodies of pertussis and diphtheria,and venous blood specimen were collected at age of 3 months without cell free DTa P inoculation,and at age of 6 months,i.e.1 month after inoculation with 3 doses of DTa P,respevtively,for detecting Ig G antibodies of pertussis and diphtheria.Total of 619 participants were stratified randomly sampled from community health crowd and their serum Ig G antibodies of pertussis and diphtheria were detected by using enzyme-limked immunosorbent assay.Information on related factors was obtained using epidemiological questionnaire through face to face interview.Results: 1.The positive rates of fetal transmission antibodies of pertussis and diphtheria in newborns were 31.06% and 33.33%,respectively.There was no statistically significant difference of the positive rates of pertussis antibody between male and female newborns.However,the positive rate of fetal transmission diphtheria antibody in male newborns(38.16%)was higher than that in female newborns(26.79%)(P<0.05).2.The negative conversion rates of pertussis and diphtheria antibodies in infants aged three months without cell free DTa P inoculation and with positive fetal transmission antibodies were 89.19% and 94.60%,respectively,and the difference was not statistically significant.But the differences of the negative conversion rates of pertussis and diphtheria antibodies between male and female infants were not statistically significant.3.The positive conversion rates of pertussis and diphtheria antibodies in infants aged six months were 76.67% and 100.00%,respectively,and the difference was statistically significant.4.4.The positive rates of pertussis and diphtheria antibodies in community health crowd were 50.57% and 60.90%,respectively,and there were no statistically significant differences between males and females.The antibody positive rate of pertussis in participants aged <15 years(36.77%)was significant lower than that in aged 15-58 years(64.40%)(P<0.05).The antibody positive rate of pertussis in participants with history of vaccination(40.94%)was significant higher than that in those without history of vaccination(16.98%)among the crowd aged <15 years,and the antibody positive rate of pertussis increased with the immune doses.However,the antibody positive rate of diphtheria in participants aged <15 years(82.08%)was significant higher than that in aged 15-58 years(40.45%)(P<0.05).The antibody positive rate of diphtheria in participants with history of vaccination(91.34%)was significant higher than that in those without history of vaccination(35.85%)among the crowd aged <15 years,and the antibody positive rate of diphtheria increased with the immune doses.The antibody positive rate of pertussis(91.34%)was significant higher than that of diphtheria(40.94%)in the participants with history of vaccination among the crowd aged <15 years(P<0.05).Conclusions: The positive rates of pertussis and diphtheria antibodies were lower in newborns,two-thirds of the newborns cannot get protection of maternal fetal transmission antibodies of pertussis and diphtheria.The negative conversion rates of pertussis and diphtheria antibodies in infants aged 3 months without cell free DTa P inoculation and with positive fetal transmission antibodies were very high,and infants aged 3 months had higher risk of pertussis and diphtheria.The positive conversion rate of pertussis antibody in infants aged 6 months was significant lower than that of diphtheria antibody.The positive rate of pertussis antibody in community health crowd were lower,especially in the crowd aged <15 years.