Epidemiology Characteristics And Antibody Levels In Some Areas Of Pertussis In Xinjiang Uyghur Autonomous Region

Objective:To master the epidemiological characteristics of Pertussis in Xinjiang Uygur Autonomous Region(Xinjiang)from year 2004 to 2015,Including the main groups of the disease,time and region distribution of the disease.To know the real antibody levels and the incidence in some areas in Xinjiang,provide references for developing the Pertussis immunization strategies of prevention and control.Methods: We analyzed the reported cases of Pertussis in Xinjiang from China disease surveillance information reporting and management system from year 2004 to 2015 using the descriptive epidemiological methods.Application of Microsoft spreadsheet(Microsoft Excel)2007 data input and statistics processing.Using random sampling method to select 9 areas for survey,each area select 100 healthy persons without coughing,wheezing and other symptoms.By age group,respectively<1 age group;1~2years old group;3~4 years old group;?5 years old group,collecting serum samples and epidemiological information,using enzyme-linked immunosorbent assay(ELISA)to detect the pertussis IgG antibody.Results: 1)A total of 5,536 pertussis cases were reported from year 2004 to 2015 with 5 death cases.The average annual reported incidence was 2.17/100,000,the main cases were distributed in southern regions,especially in Akesu,Kashi and Hetian;2)The age distribution of pertussis in Xinjiang is still in small ages,and the scattered children are the main risk group;3)The pertussis IgG antibody is different in the 9 areas,and the difference has significant(P<0.001),between this,the antibody in southern areas obviously higher than northern;4)Different ages has different IgG antibody level,<1 age group has the lowest positive rate,?5 years old group has the highest,different gender group has no difference of IgG antibody level;5)People inoculated with different doses have different level of the pertussis IgG antibody,and the difference has significant(P<0.001).Conclusions: 1)The disease incidence of pertussis in Xinjiang is still high among the nation,the main cases distribute in southern regions,small ages and scattered children are the high-risk population;2)Different area has different level of pertussis IgG antibody,it is still low in the whole Xinjiang,the onset of the crowd main in the small ages,it also has the certain seasonality;3)Fully immunized population have the high level antibody,vaccination is still the effective mean to control the outbreak of pertussis.So in the future we should be focus on the epidemiology characteristics of pertussis in key areas,and improve the vaccination rate of the target population,in order to achieve the purpose of controlling Xinjiang pertussis.