| Objective: To investigate the effects of lipid-lowering therapy on low-density lipoprotein cholesterol(LDL-C)target value of 1.8mmol / l,2.07 mmol / l and decrease of more than 50% in patients with ischemic stroke who also have arotid atherosclerotic plaque.Methods: Collect clinical data of stroke patients from June 2014 to June 2016,hospitalized in the Department of Neurology,with "carotid atherosclerotic plaque" and 6 months after discharge in our hospital.1.Comparing samples lipid-related parameters in sercum before and after the treatment in order to understand the situation of lipid management.2.Comparing samples before and after the treatment with the carotid artery color Doppler ultrasound in order to understand the overall treatment of atherosclerosis.3.Low-density lipoprotein cholesterol levels were divided into groups of 1.8 mmol / l,2.07 mmol / l and more than 50%,respectively,comparing baseline and carotid atherosclerotic plaque-related parameters.Logistic regression analysis of low-density lipoprotein cholesterol after treatment and baseline low-density lipoprotein cholesterol levels.4.Comparison of low density lipoprotein cholesterol higher than 1.8mmol / l but the degree of decline of more than 50% and low density lipoprotein cholesterol below 1.8mmol / l but less than 50% decline in the plaque length of the two groups.Results: 1.We enrolled 100 patients with ischemic stroke.There was a significant difference in total cholesterol(TC)and low density lipoprotein cholesterol(LDL-C)before and after the study(P <0.05).There was significant difference in carotid atherosclerotic plaque diameter before and after treatment(P <0.05),but there was no significant difference in the plaque thickness,intima-media thickness and the Crouse score witch often used in the literature was not statistically significant difference before and after(P> 0.05),The morphology of the plaque is the rule or not,the echo is homogeneous or not in this study before and after were no significant statistical differences(p> 0.05).2.The group of Low-density lipoprotein cholesterol levels below 1.8mmol / l has carotid atherosclerotic plaque length of about 1.11 ± 0.46 cm before treatment,The group of LDL-C higher than 1.8mmol / l has plaque length of about 1.27 ± 0.56 cm before treatment.There were no significant statistical differences between the two groups.(P >0.05).In the LDL-C level was lower than 1.8mmol / l group,the diameter of carotid atherosclerotic plaque was about 0.87 ± 0.74 cm after treatment,and in the LDL-C was higher than 1.8mmol / l group,the length of plaque was about 1.01 ± 1.03 cm after treatment,and there was significant difference between the two groups(P <0.05).3.The group of Low-density lipoprotein cholesterol levels decreased by more than 50% has carotid atherosclerotic plaque length of about 1.13 ± 0.26 cm before treatment.The group of not more than 50% has plaque length of about 1.2 ± 0.73 cm before treatment,there was no significant difference between the two groups(P> 0.05);The group of Low-density lipoprotein cholesterol levels decreased by more than 50% has carotid atherosclerotic plaque length of about 0.69 ± 0.45 cm after treatment.The group of not more than 50% has plaque length of about 1.16 ± 0.84 cm after treatment,there was significant difference between the two groups(P<0.05).4.The group of Low-density lipoprotein cholesterol less than 1.8mmol / l but not more than 50% declined has carotid atherosclerotic plaque length of about 1.06 ± 0.64 cm before treatment,LDL-C higher than 1.8mmol / l but decreased more than 50% has carotid atherosclerotic plaque length of about 1.15 ± 0.42 cm before treatment,there was no significant difference between the two groups(P> 0.05);The group of Low-density lipoprotein cholesterol less than 1.8mmol / l but not more than 50% declined has carotid atherosclerotic plaque length of about 0.98 ± 0.84 cm after treatment,LDL-C higher than 1.8mmol / l but decreased more than 50% has carotid atherosclerotic plaque length of about 0.73 ± 0.24 cm after treatment,there was no significant difference between the two groups(P> 0.05);5.The group of Low-density lipoprotein cholesterol levels below 2.07mmol/l has carotid atherosclerotic plaque length of about1.23 ± 0.52 cm before treatment,The group of LDL-C higher than 2.07 mmol / l has plaque length of about1.21 ± 0.6cm before treatment.There were no significant statistical differences between the two groups.(P >0.05).In the LDL-C level was lower than 2.07mmol/ l group,the diameter of carotid atherosclerotic plaque was about 0.97 ± 0.7cm after treatment,and in the LDL-C was higher than 2.07 mmol / l group,the length of plaque was about 0.985 ± 1.1cm after treatment,and there was no significant difference between the two groups(P >0.05).Conclusion:1.In patients with ischemic stroke,low-density lipoprotein cholesterol decreased by more than 50% or low-density lipoprotein cholesterol below 1.8mmol / l can be selected as the appropriate target,and low-density lipoprotein cholesterol below 2.07 mmol / l was not suitable as a lipid-lowering target value.2.Intensive statin therapy can reduce carotid atherosclerotic plaque burden in 6 months.3.Observation of 6 months follow-up two-dimensional color Doppler ultrasound,it is recommended to observe the carotid atherosclerotic plaque long diameter changes. |
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