Different Modes Of Artificial Liver In Drug-induced Liver Failure And Hyperbilirubinemia Application

Objective:To investigate the clinical effect of different artificial liver model in patients with drug-induced liver failure and hyperbilirubinemia,the changes of biochemical indexes,coagulation index,MELD score and clinical symptom improvement in different artificial liver models were analyzed.For the selection of relatively safe and efficient treatment model to provide a referenceMethods:Retrospective analysis was followed by specific bilirubin adsorption sequential single membrane half-component plasma exchange(study group),aseptic operation,bilirubin adsorption column was directly separated after the replacement of plasma separator;single membrane component plasma exchange(control Group)of drug-induced liver failure and hyperbilirubinemia cases,are based on comprehensive treatment of internal medicine,compared the two groups of patients with the treatment effect and the changes in the default indicators.Results:Both treatment modalities to improve liver function have played a positive role,ALB,TBIL,PTA,INR,ALT,TBA and MELD scores were improved(P <0.05),and the study group had a positive effect on the improvement of liver function.(P <0.05).There was no significant difference in AST,ALP and GGT between the two groups(P> 0.05).There was no significant difference between AST,ALP and GGT in the treatment group(P> 0.05).The differences of TBIL,TBA,GGT,PTA,INR and MELD scores between the two groups were statistically significant(P <0.05).The changes of ALB,AST,ALT,ALP and PLT before and after treatment were compared,(P> 0.05).The incidence of adverse reactions in the two groups was 25% in the study group and 75% in the control group.The incidence of adverse reactions in the control group was higher than that in the study group,the difference was statistically significant(P <0.05).Conclusion:Specific bilirubin adsorption sequential single membrane half-component plasma exchange pattern,in the case of retention of the original component plasma separator,adjuvant therapy for drug-induced liver failure and hyperbilirubinemia is a safe and effective means of single-Plasma purification mode,the removal of bilirubin,total bile acid and other harmful substances more significant,the bilirubin removal efficiency is higher,the body environment can be improved for a short time,to promote the liver repair,coagulation function and MELD score and other indicators And the incidence of plasma use,the incidence of adverse reactions is lower,can get better than the single membrane component plasma exchange better clinical effect,therefore,the artificial liver combination model as a safe,effective,economical program worthy of further promotion use.