Analysis Of Effects In Treatment Of Liver Failure Patients With Different Modes Of Artificial Liver Support System

Objective:To observe the therapeutic effects in the treatment of liver failure with different modes of artificial liver support system: PP mode?PDF mode?PP combined with PDF mode.Methods:The related data of 76 patients diagnosed as liver failure in the Second Affiliated Hospital of Nanchang University from April 2015 to February 2017 are collected.According to different artificial support modes,we divide them into three groups and then analyze the differences of therapeutic effects between three groups retrospectively.Results:1.To analyze the clinical indexes before and after treatment in three groups: After treatment,TBIL,ALT,AST in all three groups decreased and the differences in three groups were statistically significant(P<0.05);MELD scores of three groups also decreased,differences were statistically significant in PDF group and PP combined PDF group(P<0.05),but there was no statistically significance in PP group;After treatment,PTA of all three groups improved,difference was statistically significant in PDF group(P<0.05),but there were no significant differences in PP group and PP combined PDF group;After treatment,INR of both PDF group and PP combined with PDF group decreased and differences were statistically significant(P<0.05).But in PP group INR increased with no statistically significance;The levels of albumin in PDF group increased with statistically significance(P<0.05),but levels of albumin in PP group and PP combined with PDF group decreased with no statistically significance;2.To analysis the clinical indexes before and after treatment between three groups: TBIL,MELD scores decreased and PTA increased between three groups,the differences were not statistically significant(P>0.05);level of albumin in PDF group increased,but the levels of albumin in PP group and PP combined with PDF group decreased,there were no statistical differences between three groups(P>0.05);3.To compare the survival rate of patients treated with different modes of artificial liver: Twelve weeks after discharge,overall survival rate of PP group was 72.7%(eleven patients were followed up,of which eight survive),survival rate of PDF group was 70.0%(forty patients were followed up,of which twenty-eight survive),and survival rate of PP combined with PDF group was 71.4%(fourteen patients were followed up,of which ten survive),the differences between three groups were not statistically significant(P>0.05).Twenty-four weeks after discharge,overall survival rate of PP group was 62.5%(eight patients were followed up,of which five survive),survival rate of PDF group was 67.6%(thirty-seven patients were followed up,of which twenty-five survive),and survival rate of PP combined with PDF group was 55.6%(nine patients were followed up,of which five survive),the differences between three groups were not statistically significant(P>0.05);4.To compare the prognosis of patients in different stages of liver failure treated by artificial liver: Twelve weeks after discharge,overall survival rate of patients treated in early stage was 76.1%(forty-six patients were followed up,of which thirty-five survive),survival rate of patients treated in middle stage was 71.4%(fourteen patients were followed up,of which ten survive),and survival rate of patients treated in advanced stage was 20.0%(5 patients were followed up,of which one survives),the chi-square value is 0.035 and the p value is 0.983,the difference between three groups was not statistically significant(P>0.05).Twenty-four weeks after discharge,overall survival rate of patients treated in early stage was 76.1%(forty-six patients were followed up,of which thirty-five survive),survival rate of patients treated in middle stage was 71.4%(fourteen patients were followed up,of which ten survive),and survival rate of patients treated in advanced stage was 20.0%(five patients were followed up,of which one survives),the chi-square value is 0.480 and the p value is 0.787,the difference between three groups was not statistically significant(P>0.05).Conclusion:The PP mode?PDF mode and PP combined with PDF mode of artificial liver support system can all remove toxins like bilirubin effectively and improve the internal environments of liver failure patients.Survival rate of liver failure patients can be increased with all three modes,and there is no significant difference between the three modes.