Clinical Study Of Opioids Combined With Gabapentin In Cancer Pain

Object: This study aims to discover the optimal regimen for cancer pain therapy by means of observing the difference of efficacy,improvement of living quality,amount of consumption,side-effect and impact on immune system between the combination therapy of opioids and gabapentin and single-agent therapy.Method: Prospective data of 80 patients with cancer pain from medium to maximum in Qinghai hospital were collected.The patients enrolled were randomly separated into group A and B where they were treated according to the standard regimen(morphine for titration,oxicodone for maintainance).Gabapentin was added into the regimen for group B(300mg,tid,po).The difference of efficacy,improvement of living quality,amount of consumption,side-effect and impact on immune system between the two therapies was assessed and analyzed.Results:(1)The NRS score of both groups dropped.The decline degree of group B was significantly higher than that of group A(P<0.05).Improvement of living quality of both groups rose.The increase degree of group B was significantly higher than that of group A(P<0.05).The amount of medical consumption of group B was significantly lower than that of group A.The side-effects were similar in both groups.The incidence of constipation,nausea and vomiting for group B was significantly lower than that of group A(P<0.05).The function of immune system was improved in all patients enrolled.Furthermore,the immune function was significantly higher in group B(P<0.05).Conclusions: 1.Combination of opioids and gabapentin would be superior than single-agent in efficacy,improvement of living quality,amount of consumption,side-effect.2.Standard therapy for cancer pain is capable of promoting patient's immune function.Combination of opioids and gabapentin would be more effective on the promotion.