An Association Analysis Between Polymorphism Of Glutamate Receptor 6 Gene And Impulsively Aggressive Behavior In Patients With Bipolar Disorder

Objective:To explore the association between impulsively aggressive behavior and rs6922753 single nucleotide polymorphism of glutamate receptor 6(Glu R6)gene in Han and Uygur patients with bipolar disorder,in order to provide a theoretical basis for further study on the molecular genetics mechanism of impulsively aggressive behavior in patients with bipolar disorder.Methods:To study Patients which hospitalized in Department of clinical psychology of the people's Hospital of Xinjiang autonomous region and the Xinjiang mental health center from January 2015 to June 2016,and which will to accept the study and conformed to diagnostic criteria of bipolar disorder in Diagnostic and Statistical Manual of Mental Disorders Fourth Edition(DSM-?)that was developed by the American Psychiatric Association.There were 89 Han patients and 151 Uygur patients in line with the above standards.In order to avoid the influence of ethnic differences on the results of the study,the Han and Uygur patients were studied separately in this study.The basic demographic data were collected using a general questionnaire.Hamilton Depression scale(HAMD)was used to evaluate the depression status of the patients.Modified overt aggression scale(MOAS)was used to assess the patient's impulsive behavior screening,according to the results of the assessment,two groups of patients from two nationalities were divided into the group with impulsively aggressive behavior and the group with no impulsively aggressive behavior.There were 28 cases of impulsively aggressive behavior in the Han nationality,and no impulsively aggressive behavior in the case of 62 cases;47 cases of impulsively aggressive behavior in the Uygur nationality,and no impulsively aggressive behavior in the case of 104 cases.The techniques of PCR and DNA sequencing technique were conducted to detect rs6922753 single nucleotide polymorphism of Glu R6 gene in 240 patients with bipolar disorder,set up a database.Finally,SPSS17.0 software was used to respectively analyze the association between rs6922753 single nucleotide polymorphism of Glu R6 gene and impulsively aggressive behavior in Han and Uygur patients with bipolar disorder.Results:No statistical difference was observed between the impulsively aggressive behavior group and the no impulsively aggressive behavior group of Han patients with bipolar disorder in the genotype(?2=3.292,P=0.193)and allele(?2=2.181,P=0.14)frequencies for the investigated rs6922753 polymorphisms(P>0.05).No statistical difference was observed between the impulsively aggressive behavior group and the no impulsively aggressive behavior group of Uygur patients with bipolar disorder in the genotype(?2=0.389,P=0.823)and allele(?2=0.141,P=0.707)frequencies for the investigated rs6922753 polymorphisms(P>0.05).Conclusion:No association was found between the impulsively aggressive behavior and rs6922753 single nucleotide polymorphism of Glu R6 gene in Han patients with bipolar disorder.No association was found between the impulsively aggressive behavior and rs6922753 single nucleotide polymorphism of Glu R6 gene in Uygur patients with bipolar disorder.