| ObjectiveTo study the effect of Kang Quanli enteral nutritional suspension(TPF-DM)and Neng Quanli enteral nutritional suspension(TPF)on the metabolic and safety index,including blood sugar,insulin dosage,blood uric acid,albumin,prealbumin,triglyceride and cholesterol,and analyze the efficacy and safety of the treatment in patients with type 2 diabetes with hyperuricemia,which to provide a theoretical basis for the rational use of TPF-DM and TPF in clinical practice.Methods74 patients with type 2 diabetes with hyperuricemia were randomly divided into the TPF-DM group and the TPF group with 37 cases in each group.In the TPF-DM group,patients with type 2 diabetes with hyperuricemia were given TPF-DM and those in the TPF group were given TPF by detaining gastric tube.The liquid intake and output volume and the insulin dosage of patients in both groups were recorded in detail.Fasting venous blood samples were taken before enteral nutrition,and at 7th and 10 th day after enteral nutrition to measure the metabolic index of blood sugar,blood uric acid,albumin,prealbumin,triglyceride and cholesterol,and the adverse reactions and complications in patients with enteral nutrition in both groups were recorded in detail.The repeated measurement,t-test and c2 test were used to analyze the data collected for statistical analysis.Results35 cases were effective in each group.1.Compared by the two groups,it was comparable that there was no statistically significant in the general data and baseline value of the index before enteral nutrition(P>0.05).2.There was statistically significant in the time effect,the treatment effect,and the interaction effect,by repeated measurements of the insulin dosage(Ptime=0.039,Ptreament=0.025,Pinteraction<0.001).Compared by the insulin dosage in different time,the dosage in the TPF-DM group was lower than that in the TPF group at 7th and 10 th day,and the difference was statistically significant(t=2.206,P=0.031;t=3.579,P=0.001).3.There was statistically significant in the time effect,the treatment effect,and the interaction effect,by repeated measurements of the blood sugar level(Ptime=0.006,Ptreatment<0.001,Pinteraction<0.001).Compared by the blood sugar level in different time,the level in the TPF-DM group was lower than that in the TPF group at 7th and 10 th day,and the difference was statistically significant(t=4.071,P<0.001;t=4.799,P<0.001).4.During the enteral nutrition,there was no significant difference between the two groups in the intake and output(P>0.05),so the influence on blood uric acid level could be excluded.The blood uric acid level in the TPF-DM group increased from(494.83 ± 60.82)?mol/L to(499.51 ± 63.20)?mol/L,but there was no statistically significant in the time effect,the treatment effect,and the interaction effect,by repeated measurements of the blood uric acid level(Ptime=0.578,Ptreatment=0.893,Pinteraction=0.066).5.During the enteral nutrition,the time effect of albumin in the two groups was statistically significant(Ptime<0.001),while the treatment effect and the interaction effect were no statistically significant(P>0.05).There was statistically significant in the time effect,the treatment effect,and the interaction effect,by repeated measurements of the prealbumin level(Ptime<0.001,Ptreatment=0.044,Pinteraction<0.001).Compared by the prealbumin level in different time,the level in the TPF-DM group was higher than that in the TPF group at 10 th day,and the difference was statistically significant(t=2.823,P=0.006).6.During the enteral nutrition,there was no statistically significant in the time effect,the treatment effect,and the interaction effect,by repeated measurements of the triglyceride level(P>0.05),with the decreased level in the TPF group and the increased level in the TPF-DM group.There was statistically significant in the time effect,the treatment effect,and the interaction effect,by repeated measurements of the cholesterol level(Ptime<0.001,Ptreatment=0.043,Pinteraction=0.036).Compared by the cholesterol level in different time,the level in the TPF-DM group was higher than that in the TPF group at 10 th day,and the difference was statistically significant(t=2.435,P=0.018).7.There was no significant difference between the two groups in the incidence of adverse reactions and complications(P>0.05).ConclusionsIn the short term(10 days),the TPF-DM can have the advantages of more stable blood sugar level,less insulin dosage and better protein metabolism than the TPF,and the TPF can be better to improve the cholesterol level.In addition,there is no significant effect on the level of blood uric acid and triglyceride,which shows that the TPF and the TPF-DM are safety for patients in the short term(10 days).Therefore,the TPF and the TPF-DM can have certain curative effect on patients with type 2 diabetes with hyperuricemia.Besides,the TPF-DM is better for the patients with type 2 diabetes with hyperuricemia in the short term(10 days),but the risk of elevated blood uric acid levels in patients should be noted for long time use. |
PDF Full Text Request