The Clinical Significance Of FeNO In Long-term Outcomes Of Infants With Bronchiolitis

Objective Observe specific immunoglobulin E(s Ig E),serum Ig E,peripheral blood eosinophilia(EOS),fraction exhaled nitric oxide(Fe NO)and the incidence of wheeze and asthma in the future to investigate the clinical significance of Fe NO in longterm outcomes of infants with bronchiolitis.Methods According to the inclusion criteria,we selected 100 Children of bronchiolitis from December 2015 to February 2016 in our hospital,divided the bronchiolitis patients into atopic and non-atopic groups,each group has 50 cases.Both groups were given Fe NO,serum Ig E,peripheral blood EOS detected and analyzed in the acute phase,1 month and 3 months after treatment.We both compared the incidence of wheeze and asthma of two groups.Results(1)The Fe NO,serum Ig E and EOS of atopic group were higher than those in non-atopic group(P <0.05),whether in the acute stage or 1 month and 3 months after treatment.(2)The Fe NO,as well as the Ig E and EOS of the atopy group in 1 month and 3 months were significantly lower than that in the acute stage(all P<0.05).(3)The Fe NO,as well as the Ig E and EOS of the non-atopic group after treatment in 1 month and 3 months decreased gradually compared with the acute phase.The differences were statistically significant(all P<0.05).(4)During the follow-up period of 6 and 12 months,the frequency of wheezing episode and asthma of the atopic group were higher than those of non-physical group,and the differences were statistically significant(P < 0.05).(5)There was a significantly positive correlationship between the Fe NO of the atopic group and the number of wheezing episode in the follow-up period of 6 and 12 months.Conclusion(1)The Fe NO,serum Ig E and EOS of atopic group were higher than those in non-atopic group in the acute stage,1 month and 3 months after treatment.The incidence of wheeze and asthma in atopic group were higher than those of non-physical group.It may suggest that the atopic constitution is a high risk factor for the development of bronchiolitis to asthma.(2)The incidence of wheeze and asthma of the atopic group were higher than the non-atopic group,which were correlated to Fe NO.It may suggest that higher level of Fe NO could be predicte recurrent wheezing and development to asthma of the bronchiolitis children.