| Objective: In this study,we come to know the relationship between serum G17 and gastric cancer and precancerous lesions by detecting the levels of serum G17 in carcinogenesis of gastric mucosa,and to clarify the dynamics of serum G17 in the progression of gastric cancer.So we can explore the application of serum G17 as a screening and early diagnosis of gastric cancer.We observe the changes of serum G17 before and after Hp eradication,and know the correlation between Hp infection and serum G17 to determine whether it can be used as clinical index of Hp eradication.Meanwhile,we can know the infection rate of Hp and the Hp eradication rate by using bismuth-containing quadruple program in Yan’an area.Methods:We Selected 899 patients in Yan’an University Affiliated Hospital in this study.The subjects were divided into non-atrophic gastritis,gastric ulcer,chronic atrophic gastritis,gastric dysplasia and gastric cancer group by endoscopy and biopsy.The subjects did the 14 C UBT and serum G17 detection before the endoscopy.The subjects(except gastric cancer)who infect Hp were given bismuth-containing quadruple eradication program for 2 weeks,and did 14 C UBT and serum gastrin 17 detection again after 4 weeks.The data collected were analyzed by SPSS20.0 software.Result:1.There was no significant difference in serum G17 levels between men and women(t =0.763,P = 0.446).So was there between subjects in the age group ≤ 60 years old and subjects in the age group > 60 years old(t = 1.02,P = 0.310).2.There was significant difference in sex among the five groups(χ = 69.22,P =0.000).The proportion of men and women in the GU group was different from that in NAG,CAG and GD group(χ= 69.22,P = 0.000;χ= 61.25,P = 0.000;χ= 26.43,P =0.000).The proportion of men and women in the GC group was different from that in NAG and CAG group(χ= 11.48,P = 0.001;χ= 7.04,P = 0.008).There was more men than women in GU group and GC group.The proportion of men and women in the GU group was 3.97: 1,and it in the GC group was 3: 1.The age of subjects gradually increased from NAG,GU,CAG,GD to GC.The difference in age of the five groups was statistically significant(F = 7.71,P = 0.000).3.The 95% confidence interval of Hp infection in Yan’an area was 41.7%-48.2%.There were significant differences in Hp infection rates among the five groups(χ = 79.02,P =0.000).The Hp infection rate of GU is the highest.The Hp infection in GU was significantly different from that in NAG,CAG and GD(χ= 69.94,P = 0.000;χ= 17.73,P= 0.000;χ= 8.58,P = 0.003),but there was no significantly difference in Hp infection between GU and GC(χ=17.73,P=0.648).The Hp infection rate in GC was lower than that in GU,and it was significantly different from that in NAG and CAG(χ= 14.77,P =0.000;χ= 5.11,P = 0.024),but there was no significantly difference in Hp infection between GC and GD(χ= 2.376,P = 0.123).4.The Hp eradication rate of 95% confidence interval in Yan’an area was 88.2%-94.3%.There was no significant difference in Hp eradication rate among the four groups(χ = 0.97,P = 0.841).5.Serum G17 levels were significantly different among NAG,GC,CAG,GD and GC(F= 59.68,P = 0.000).The serum G17 increased significantly from NAG to GU stage.It decreased significantly from GU to CAG stage.And it increased again from CAG to GD stage.It further increased from GD to GC stage,but there was no statistical difference in serum G17 between the two groups(P = 0.092).6.The levels of serum G17 in Hp infected subjects were higher than those uninfected in NAG,GU,CAG and GD.There was no significant difference in serum G17 between the infected and uninfected in GC group(t =-0.82,P = 0.422).7.The levels of serum G17 were significantly decreased after successful treat of Hp infection in NAG,GU,CAG and GD group,and there was statistical difference before and after treat(P <0.05).There was no significant difference in serum G17 before and after a failure treat(P> 0.05).Conclusion:1.Sex and age had no significant effect on serum G17;2.There was more men than women in GU and GC;3.The 95% confidence interval of Hp infection in Yan’an area was 41.7%-48.2%,the highest rate of Hp infection is GU,followed by GC;4.The 95% confidence interval of Hp eradication by standard quadruple therapy with bismuth in Yan’an area was 88.2%-94.3%;5.The serum G17 increased significantly from NAG to GU stage.The serum G17 decreased significantly from GU to CAG stage.The serum G17 increased again from CAG to GD stage;6.Hp can increased serum G17 level in NAG,GU,CAG and GD;7.The serum G17 level decreased significantly after Hp eradication in NAG,GU,CAG and GD.This need further study to know if serum G17 may be used as a relaible marker to evaluate the Hp eradication. |
