Study On The Relationship Of Hyperhomocysteinemia With Mild Cognitive Impairment And Alzheimer's Disease

Objective:To investigate the relationship of Hyperhomocysteinemia(hereinafter referred to as Hhcy)with mild cognitive impairment(hereinafter referred to as MCI)and Alzheimer's disease(hereinafter referred to as AD)Methods:Inpatients are randomly selected with the age of 65 or above entering our hospital between July,2014 and March,2016.Three groups are divided based on AD and MCI diagnostic criteria after sifting through inclusion and exclusion standards.The AD patients are diagnosed using DSM-IV–TR,while the MCI patients are diagnosed using Petersen's MCI criteria.Patients selection and grouping are homogenized against risk factors including hypertension,diabetes,smoking and drinking.Group I consists of 45 patients with normal cognition.Group II consists of 40 MCI patients.Group III comprises 76 AD patients.All subjects are assessed through MMSE in terms of cognitive function,along with blood tests to reveal tHcy in the serum,followed by correlation analysis between the tHcy data and the indicators of cognitive function.Then the research attempts to find out whether the decrease of MMSE scores is related to the value of tHcy.SPSS19.0 is used for statistical analysis,with measurement data expressed in mean standard deviation((?)±s).The means between independent samples from the case group and the control group are compared using t test(using approximate t test if equal variances not assumed).Multivariate analysis is conducted via logistic regression.The correlation between tHcy and cognition is based on Pearson correlation analysis,taking P<0.05 for effective statistical difference and P<0.01 for statistically significant difference.Results:1.Comparison of tHcy for Three GroupsThe AD Group posts a value of 19.783±6.857 umol/l.The MCI Group posts 18.035±6.663 umol/l and the control group 14.213±4.386 umol/l.All three groups present normal distribution in tHcy level.Statistical comparison are conducted between case groups and the control group using T test.The density of tHcy for AD group is significantly higher versus the control group,delivering significant difference(P<0.01).The density of tHcy for MCI group is significantly higher compared with the control group,showing significant difference(P<0.01).2.Correction between MMSE Scores and tHcy within Case GroupsThe MMSE score is17.815±5.930 for AD Group and 25.581±1.065 for MCI Group.The Pearson analysis on the correlation between MMSE score and tHcy within AD Group suggests significant negative correction(r=-0.568,P<0.01),while MMSE score and tHcy show no significant correlation within MCI Group Conclusion:This research suggests that Hhcy may be another risk factor for AD and MCI.Positive control of Hhcy has some effects on the prevention and delay of AD and MCI in clinical practice.