The Effectiveness Of Laryngeal Papilloma Instrument Resection And The CO₂ Laser Therapy: Meta-analysis

Background: Laryngeal papilloma is a high-risk,high recurrent and have the characteristics of malignant transformation diseases.There is a wide variety of treatments and new treatments are emerging.There are two kinds of treatments for the treatment of conventional surgery and CO₂ laser.But there is no cure for radical treatment.Purpose: Through the Meta-analysis to compare Recurrence rate,cure rate and remission rate after the conventional surgery and the CO₂ laser therapy,if there is a difference.Methods: Searching in the English database: including PubMed,Embase,the Cochrane library.Using Chinese retrieval database: including Wan-Fang database,VIP database,China National Knowledge Infrastructure and SinoMed.Find all the literature on the comparison of the conventional surgery and the CO₂ laser therapy.Data extraction and quality evaluation of the included documents.And meta analysis of data with RevMan5.3 software.Results: A total of 10 documents are included in this meta-analysis and the result shows that recurrence rate after CO₂ laser therapy is lower?OR=0.50,95%CI?0.36,0.70?,P<0.01?,the cure rate and the overall response rate are higher?OR=2.88,95%CI?1.88,4.42?,P<0.01?,?OR=2.52,95%CI?1.30,4.90?,P<0.01?.Meanwhile,The data suggest that the post-operative remission rate is higher.?OR=0.44,95%CI?0.27,0.70?,P<0.01??Conclusion: The method of removing laryngeal papilloma with CO₂ laser is much better than the conventional surgery.