A Retrospective Study Of Hybrid Therapy For The Acute Whole Deep Venous Thrombosis With Combination Of Traditional Chinese Medicine And Western Medicine

Objective: To explore the curative effect of combination of traditional Chinese and Western medicine treatment in the application systemic thrombolysis and catheter-directed thrombolysis intervention in the acute whole deep venous thrombosis,and provide objective basis for optimal treatment of deep venous thrombosis.Methods: Collecting the Affiliated Hospital of Shandong University of Traditional Chinese Medicine from January 2006 to December 2015 in the acute whole and damp heat type deep venous thrombosis in patients with a total of 240 cases.Give Simiao Yongan decoction plus oral,ice powder external use,low molecular heparin calcium bridging warfarin,and through the peripheral venous and thrombolytic catheter to give urokinase.According to the combination of traditional Chinese and Western medicine scheme to different drug urokinase for systemic thrombolysis group 178 cases,62 cases of catheterdirected thrombolysis group,analyzing the characteristics,efficacy and safety.Results: 1.The clinical cure rate(48.39%)of catheter-directed thrombolysis group was higher than that of systemic thrombolysis group(29.78%),and the difference was very significant(P<0.01).2.The symptoms and signs of catheter-directed thrombolysis group and systemic thrombolysis group were very significantly lower than those before treatment(P<0.01).3.The fibrinogen level of the two groups was very significantly lower than those before treatment(P < 0.01).Compared with systemic thrombolysis group,fibrinogen in catheter-directed thrombolysis group was significantly lower(P < 0.05,P < 0.01).4.In systemic thrombolysis group,the D-Dimer level of the 7 and the 14 day after treatment was lower than those before treatment(P<0.01).In catheter-directed thrombolysis group,the level of D-Dimer increased first and then decreased after treatment(P<0.01).The changes of D-Dimer in catheter-directed thrombolysis group were higher than those in systemic thrombolysis group at the 3 day and the 7 day after treatment,and the difference was very significant(P<0.01).There was no significant difference between the two groups the 14 day after treatment(P>0.05).5.All the patients with venous patency score were significantly decreased than before treatment(P<0.01).Catheter-directed thrombolysis group was lower than systemic thrombolysis group,and the difference was significant(P<0.05).There was no significant difference between the 7 day after catheter-directed thrombolysis and the 14 day after systemic thrombolysis after treatment(P>0.05).6.Compared with the 14 day after treatment,the venous patency rate of the patients in the two groups increased significantly after the treatment for 28 days(P < 0.01).The venous patency rate of catheter-directed thrombolysis group was higher than that of systemic thrombolysis group(P<0.01).7.There was no significant difference between the two groups patients(P>0.05).The use time of urokinase in catheter-directed thrombolysis group was shorter than that of systemic thrombolysis group(P<0.01).8.The hospitalization time of catheter-directed thrombolysis group was shorter than that of systemic thrombolysis group(P<0.01).Conclusion: The overall plan of Integrated Traditional Chinese and Western medicine for the treatment of deep venous thrombosis has a significant effect,can effectively relieve the symptoms and signs of patients,promote the recanalization of the vein.Catheter-directed thrombolysis can quickly open the blocked vein,protect the function of venous valve,and shorten patient stays.