Relationship Between Thyroid Nodules And Metabolic Syndrome And Its Components In 10894 People Receiving Routine Examination

Objective: To analyze the clinical and laboratory features of thyroid nodule(TN)and metabolic syndrome(MS),and to explore the relationship of them,and to screen the risk factors of TN,and to provide reference for clinical diagnosis and treatment.Methods: Clinical data that accepted in the Health Management Centre of Qian Fo Shan Hospital from Jun.2013 to Dec.2015 have been retrospectively analyzed.The laboratory examinations and the thyroid ultrasound were analyzed to characterize their features and explore their possible risk factors to TN.Results: 1.A total of 10894 cases were enrolled in this study,including 5515 men and 5379 women.There were 5564 patients with TN and the total prevalence was 51.07%.The prevalence of male was significantly lower than that of female(47.29% vs.54.95%,P < 0.01).Also the prevalence of TN ahd MS increased with age,and they were statistically significant in the same age group(P<0.01).2.Individuals were divided based on gender and the existence of TN.In male, individuals who have TN have higher age,body mass index(BMI),systolic blood pressure(SBP),fasting blood glucose(FPG),glycosylated hemoglobin A1c(Hb A1c),low density lipoprotein cholesterol(LDL-C),uric acid(UA)and the prevalence of MS,and they were statistically significant(P<0.05).In female,individuals who have TN have higher age,BMI,SBP,diastolic blood pressure(DBP),FPG,Hb A1 c,totalcholesterol(TC),triglyceride(TG),LDL-C,UA,sialic acid and the prevalence of MS,and lower high density lipoprotein-cholesterol(HDL-C),and they were statistically significant(P<0.05).3.According to the existence of MS,subgroup analysis was used to recognize the differences of clinical features between groups.It was found that there were statistically significant in gender,age,BMI,SBP,DBP,FPG,Hb A1 c,TC,TG,LDL-C,HDL-C,UA,FT3,FT4,sialic acid and the prevalence of TN(P<0.01).4.Multivariate logistic regression analysis showed that the prevalence of TN associated with gender,age,BMI,SBP,DBP,FPG,TC,LDL-C and UA,and the results were statistically significant(P<0.05).Moreover,female,the old and higher LDL-C has relationship with the prevalence of TN.Subjects were subgrouped based on BMI,blood pressure,LDL-C and FPG.Chi-square test reflected that the prevalence of TN was higher in the overweight group,hypertension group,hyperglycemia group and higher LDL-C group and the difference between the other groups were statistically significant(P<0.01).5.Multiple linear regression correlation analysis showed that BMI,SBP,DBP,Hb A1 c,TC,TG,LDL-C,HDL-C and UA has linear regression relationship with FT3;SBP,DBP,Hb A1 c,TC,TG,LDL-C,HDL-C and UA has linear regression relationship with FT4;SBP,TC,TG,Hb A1 c,and LDL-C has linear regression relationship with TSH.But the respective variables can explain the dependent variable the percentage is low,affected by other factors and accidental factors significantly.6.Based on the age and level of serum TSH,the results showed that the changes in thyroid function was correlate with and TN.Elevated serum TSH level is a risk factor for the increased prevalence of TN,and the serum level of TSH was influenced by gender and age.Conclusions: 1.The prevalence of TN was 51.07%,and there was a positive correlation between TN and MS.2.Female,elderly,overweight,hypertension,hyperglycemia,dyslipidemia and abnormal uric acid are the independent risk factor of the prevalence of TN.3.The incidence of TN in MS group was significantly higher than that in non-MS group.4.Higher blood pressure,hyperglycemia,dyslipidemia and uric acid may potential associated with the changes of thyroid function.5.Elevated TSH level is one of the risk factors of TN,and the level of TSH was correlated with gender and age.