| Purpose:This study compares the differences of laboratory indicators between hyperthyroidism patients with thyroid nodules and hyperthyroidism patients without thyroid nodules(TN),and carries out syndrome differentiation and classification according to the symptoms and signs of patients with traditional Chinese medicine,to explore the risk factors of hyperthyroidism with thyroid nodules and the distribution characteristics of TCM syndrome types,in order to provide theoretical basis for hyperthyroidism patients to avoid the occurrence of thyroid nodules as soon as possible.Material and method:This paper selected patients with hyperthyroidism who met the diagnostic criteria of traditional Chinese medicine and western medicine and were initially diagnosed as hyperthyroidism in the outpatient department of the affiliated hospital of Liaoning University of Traditional Chinese Medicine from September 2020 to December2022,after screening by exclusion criteria,183 patients who met the criteria were selected as the study subjects,including 85 cases of hyperthyroidism with thyroid nodules and 98 cases of hyperthyroidism without thyroid nodules.The basic information and physical and chemical examination results of patients were collected,including: gender,age,course of disease,body mass index,free triiodothyronin,free thyroxine,thyroid stimulating hormone,thyrotropin receptor auto-antibodies,thyroglobulin antibodies,thyroid peroxidase antibody,thyroid color ultrasound results,TCM symptoms and signs(including tongue picture and pulse picture),and the self-rating anxiety scale(SAS)were inquired and scored.With reference to the Guiding Principles of Clinical Research on New Chinese Medicines: Trial Implementation [1]and the Internal Medicine of Traditional Chinese Medicine [2],and with reference to the tutor’s clinical experience for many years,according to the symptoms and signs of patients in traditional Chinese medicine,the patients were divided into five TCM syndrome types: Qi stagnation and phlegm coagulation syndrome,liver depression and spleen deficiency syndrome,liver fire exuberance syndrome,heart and liver yin deficiency syndrome,and qi and yin deficiency syndrome.After the data collection is completed,an Excel tabular database will be developed,and SPSS 25.0 statistical software will be used for data analysis.The quantitative data will be expressed in(?)±s,the independent sample t-test will be used to conform to the normal distribution between the two groups,and the non-parametric test will be used to conform to the normal distribution between the two groups,and the median(four-digit score)[M(P25,P75)] will be used to represent;The composition ratio of quantitative data is expressed by n(%),and the Chi-square test is adopted.The binary logistic regression was used to analyze the relevant risk factors of hyperthyroidism with TN,and the rank regression was used to analyze the distribution of TCM syndrome types of hyperthyroidism with TN and the correlation between TCM syndrome types and various factors.P<0.05 indicates that there is statistical difference,and P<0.01 shows significant statistical difference.Results:1.Comparison of general data between the two groups: 183 patients with hyperthyroidism were included in this study and divided into two groups,including 85 cases(46.45%)in the hyperthyroidism with TN group and 98 cases(53.33%)in the hyperthyroidism without TN group.The age and SAS scores of hyperthyroidism with TN group were significantly higher than those of hyperthyroidism without TN group(P<0.05);The FT3 of hyperthyroidism with TN group was lower than that of hyperthyroidism without TN group,with statistical difference(P<0.05).2.Analysis of risk factors of hyperthyroidism with TN: Logistic regression analysis showed that age and high SAS score were independent risk factors of hyperthyroidism with TN(P<0.05).3.The distribution characteristics of traditional Chinese medicine syndrome types in hyperthyroidism with TN group: 12 cases(79.59%)of heart liver yin deficiency syndrome>36 cases(59.02%)of qi yin deficiency syndrome>11 cases(55.00%)of qi stagnation and phlegm coagulation syndrome>15 cases(38.46%)of liver fire hyperactivity syndrome>11 cases(23.91%)of liver stagnation and spleen deficiency syndrome.Conclusion:1.The higher the FT3 of hyperthyroidism patients,the lower the risk of thyroid nodules.2.The older the age,the more anxious the hyperthyroidism patients are the greater the risk of thyroid nodules.3.The highest proportion of hyperthyroidism patients with thyroid nodules is heart liver yin deficiency syndrome,followed by qi yin deficiency syndrome. |
