The Correlation Of Erectile Dysfunction And Peripheral Neuropathy In Type 2 Diabetes Mellitus Patients

Objective:Diabetic erection dysfunction(DED)and diabetic peripheral neuropathy(DPN)are common chronic complications in Type 2 diabetes mellitus(T2DM)patients.However,limited epidemiological studies showed a positive association between erectile dysfunction(ED)and diabetic neuropathy.There no studies have been reported in Chinese population.This study aims to investigate the correlation between diabetic erectile dysfunction(DED)and DPN.Methods:1.121 T2 DM inpatients were enrolled from November 2016 to January 2017(n=121)in the department of Endocrinology and Metabolism in the Second Affiliated Hospital of Nanchang University.International index of erectile function-5(IIEF-5)was used to evaluate the status of ED,Toronto clinical scoring system(TCSS)was used to evaluate the status of DPN.All the patients were performed nerve conduction velocity(NCV).2.According to IIEF-5,these patients were grouped to severe(Score 5~7),moderate(Score 8~11),mild(Score 12-21)and non-ED(Score ? 22).Additionally,patients with DPN were grouped to non-DPN(Score ? 5),mild-to-moderate(Score 6-11),severe(Score ?12).The prevalence of ED and DPN were calculated.3.The general,clinical and serological characteristics of these groups were compared by univariate analysis.Estimations of crude Odds ratio(OR)and their 95% confidence interval(95% CI)were calculated by logistical regression analysis for ED in relation to DPN.Results:1.Among the 121 participants with T2 DM,the prevalence of general,mild,moderate,and severe ED were 87.6%,40.50%,19.01%,and 28.10%,respectively.Moreover,general,mild to moderate and severe DPN were52.07%,35.54% and 16.53%,respectively.2.In the univariate analysis model,it suggested that 10 variables were significant difference(all P < 0.05)[age,the duration of T2 DM,Glycosylated hemoglobin(HbA1c),fasting blood-glucose(FBG),2-hour post-prandial blood glucose(2BPG),free testosterone(FT),DPN,drinking,smoking and hypertension] between ED and non-ED group.3.DPN was positively associated with mild,moderate and severe ED by binary logistic regression.After adjustment for age,the duration of T2 DM,HbA1c,FT,FBG,2hPBG,drinking,smoking and hypertension,DPN was positively associated with moderate(OR 1.5,95%CI 1.25-3.37)and severe ED(OR 2.1,95%CI 1.78-5.96),but not mild ED(OR 1.2,95%CI 0.82-2.89),respectively.Conclusions:1.The prevalence of ED in hospitalized male T2 DM patients was 87.6%,and the prevalence of ED in patients with T2 DM and DPN was higher than those without DPN.2.DPN was independently positively associated with moderate and severe ED in T2 DM patients aged 30-60 years.3.The severity of ED has a certain level correlation with the severity of DPN in type 2 diabetes mellitus patients.