The Relationship Between Primary Hypothyroidism And Epicardial Adipose Tissue Thickness

Objective: To probe the relationship between primary hypothyroidism caused by autoimmune disease and epicardial adipose tissue thickness.Method : A total of 46 primary hypothyroidism patients(primary hypothyroidism group)from June 2014 to June 2015 were enrolled,32 healthy people were selected as control group.The general information and laboratory test results were collected,the epicardial adipose thickness was measured by cardiac color ultrasound.Results : The epicardial adipose tissue thickness(EATT), cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C), lipoprotein A(Lp(a ) ),C-reactin protein(CRP), creatine kinase(CK) , thyroid peroxidase antibody(TPOAb)in primary hypothyroidism patients were significantly higher than control group; The epicardial adipose tissue thickness was positively correlated with course of disease, cholesterol,thyrotropic hormone,triglyceride,low density lipoprotein cholesterol,lipoprotein A, C-reactin protein, creatine kinase, thyroid peroxidase antibody(r=0.905,0.989,0.970, 0.933, 0.817, 0.830,0.933, 0.991, 0.919, 0.945,P<0.01);it was negatively correlated with free triiodothyronine, free thyroxine (r=-0.993, 0.969, P<0.01);Epicardial fat tissue thickness increased with the rise of thyroid stimulating hormone(TSH) and thyroid peroxidase antibody(TPOAb) levels,and reduced with the increase of free triiodothyronine(FT3) and free thyroxine(FT4).Conclusions: Compared with healthy peopel,the epicardial adipose tissue thickness was significantly increased in the primary hypothyroidism; the epicardial adipose tissue thickness increased with the increase of the degree of hypothyroidism.