The Analysis Of Risk Factors Related To The Hospital Acquired Infection In Primary Nephritic Syndrome

Objective To investigate the risk factors related to the occurrence of hospital acquired infection in patients with adult primary nephrotic syndrome.Methods A case-control study was employed by retrospective. Patients who diagnosed with primary nephrotic syndrome during hospitalization in the First Affiliated Hospital of Guangxi Medical University, Department of Nephrology,a total of 182 patients hospitalized between January 1, 2014 and December 31, 2015 were included in. There are .82 patients with hospital acquired infection were included in the observation group, the remaining without hospital acquired infection as a control group. Thirteen clinical indicators were collected in both groups, including age, gender, albumin,immunoglobulin, 25-hydroxy vitamin D3, etc. Adopt single factor Logistic regression analysis and multi-factor unconditioned Logistic regression analysis.Results Single factor Logistic regression analysis showed that the patient's hemoglobin,albumin, immunoglobulin G, 25-hydroxy vitamin D3, CD4+T lymphocyte count, 24h urinary protein and the hospitalization time were correlated with hospital acquired infection. Multi-factor unconditioned Logistic regression analysis showed that the independent risk factors related to the hospital acquired infection in the patients with adult primary nephrotic syndrome were serum albumin (OR=1.598, P<0.000), 25-hydroxy vitamin D3(OR=1.469, P <0.000), immunoglobulin G (OR=1.295, P < 0.000),CD4+T lymphocyte count (OR=1.002, P=0.020), the hospitalization time (OR=0.829,P=0.004).Conclusion 1.The levels of the hemoglobin,albumin, IgG, 25-hydroxy vitamin D3, CD4+ T lymphocyte count were more lower in the primary nephrotic syndrome patients with the nosocomial infection than the primary nephrotic syndrome patients without the nosocomial infection, while the 24-hour urinary protein level more high, hospital longer. 2.The independent risk factors of hospital acquired infection in the patients with adult primary nephrotic syndrome were serum albumin, 25-hydroxy vitamin D3,immunoglobulin G,CD4+T lymphocyte count and the hospitalization time. In clinic for patients with these factors should pay particular attention to the prevention of hospital acquired infection.