Analysis Of Risk Factors For Hospital Acquired Acinetobacter Baumannii Infection

Objective: The aim of this study was to identify risk factors for hospital acquiredAcinetobacter baumannii infection so as to provide guidances for clinical prevention andtherapy.Method:A1:1matched retrospective case-control study was performed in ShanghaiFirst People’s hospital from Jan1st2011to Jun30th2012.59patients with hospitalacquired Acinetobacter baumannii infection were investigated in our hospital,59controlswho did not suffer from infection were also investigated. The case and control matchingfactors were the same diagnosis, the same gender，the similar age(±5years), the similarAPHACHE II scores and length of stay(LOS) for over48hours.The data were analyzedby the univariate and multi-variate conditional logistic regression analysis.Result:The total incidence of hospital acquired Acinetobacter baumannii infection inour hospital was0.14%.The univariate analysis showed that risk factors associated withAcinetobacter baumannii infection include ICU stay for over7days, underlying diseases,invasive mechanical ventilation, arterious or venous catheter, abuse of broad-spectrumantibiotics, infected with other microorganisms, total parenteral nutrition, application ofimmunosuppresive agents or corticosteroids, wound drainage or medical implant, andsurgical procedures（P＜0.05）,while multi-variate conditional logistic regression analysisindicated that5independent risk factors were screened out from the10factors, includingICU stay, underlying diseases, mechanical ventilation, infections with othermicroorganisms, wound drainage or medical implant（P＜0.05）.Conclusion： ICU stay, mechanical ventilation, underlying diseases, wound drainageor medical implant are the risk factors for hospital acquired Acinetobacter baumanniiinfection.