| Purpose:To observe and study the clinical effect of Gu Hong injection in treating patients with vascular cognitive impairment of none dementia.To provide reliable theoretical basis and clinical basis for the clinical use of traditional Chinese medicine and Western medicine in the treatment of non dementia vascular cognitive impairment.Means:According to the inclusion criteria,60 patients with non dementia vascular cognitive impairment were randomly divided into treatment group and control group,each with30 cases.The treatment group was treated with intravenous injection of 20 ml Guhong injection diluted.Once a day,continuous intravenous drip for 20 days,the middle interval 10 days for a course of treatment.The research cycle has a total of 3 courses.Meanwhile,the treatment group oral donepezil hydrochloride tablet 5mg at a time,once a day.the control group oral donepezil hydrochloride tablet 5mg at a time,once a day.During treatment,the vascular risk factors for two groups of patients are corresponding treatment,but not using other educational or psychiatric drugs.Before the treatment,The changes of Mo CA,MMSE,ADAS-cog,CIBIC-plus,ADL and TCM syndrome integral and the occurrence of adverse reactions were observed before the treatment,after the second course of treatment and the third course of treatment.Result:1.Efficacy Evaluation1.1 Clinical general impression The total effective rate of CIBIC-plus evaluation in treatment group was higher than that of control group after three courses of treatment(p<0.05),indicating that the total effective rate of CIBIC-plus evaluation about treating non dementia vascular cognitive impairment was better than the control group.1.2 Cognitive Function ADAS-cog score:The two groups through three courses of treatment,compared with the same period before and after treatment were improved,the difference was statistically significant(P<0.05 or P<0.01).There was significant difference between the two groups(P<0.01).Obviously,among them,the memory,the practice ability and the speech ability of the treatment group were better than those of the control group.The control group was better than the treatment group only in directive force(p<0.05).Mo CA score:After two courses of treatment,the total score of Mo CA in the treatment group was higher than that before treatment,the difference was statistically significant(P<0.05).Among them,the treatment group was better than the control group in terms of naming and language ability,the difference was statistically significant(P < 0.05).After three courses of treatment,the total score of Mo CA in the two groups was further increased(P<0.01).The treatment group was better than the control group in naming,language ability,visual space and executive ability,orientation and other sub items(P<0.05).MMSE score,:After two courses of treatment,compared with before the treatment,the total score of MMSE in the two groups were improved.the difference was not statistically significant(P>0.05).After three courses of treatment,the total score of MMSE in the two groups was further increased(P<0.05 or P<0.01).Compared the two groups,the treatment group was better than the control group(P<0.05).Among them,the calculation,the concentration,the delayed memory and the immediate memory in the treatment group was better than the control group.1.3Activities of Daily Living After two courses of treatment,the ADL score of both groups improved(P<0.05);Compared the two groups,There was no significant difference between the two groups (P > 0.05).After three courses of treatment,the ADL score of both groups decreased further(p<0.05).The effect of the treatment group was better than the control group(p<0.05).1.4 TCM Syndrome Scores The total effective rate of the treatment group(83.33%)was higher than that of the control group(69.23%),the difference was statistically significant(p<0.05),indicating that the treatment group was better than the control group.After two courses of treatment,the total score of the treatment group decreased,the difference was statistically significant(p<0.05).After three courses of treatment,the total score of TCM syndromes in the two groups decreased,and the difference was statistically significant(P < 0.05).Among them,the kidney deficiency type,the turbid phlegm obstruction type and the blood stasis obstructing collarerals of the treatment group were better than the control group(P<0.05).2.Safety Assessment During treatment and follow-up,no significant adverse reactions were observed in both groups.The laboratory examination showed no obvious abnormal changes before and after treatment.Conclusion Guhong injection can significantly improve the cognitive ? daily living ability and syndrome scores of TCM of patients with non dementia vascular cognitive impairment,and has no obvious adverse reactions,is a safe and effective drug for the treatment of non dementia vascular cognitive impairment. |
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