The Correlations Between Serum Lipids Level And Birth Weight During The First,Second And Third Trimester

Objectives:1.To investigate the correlation between level of serum lipids during pregnancy and birth weight.2.To provide clinical basis for guiding a reasonable diet for pregnant women,prevention of adverse pregnancy outcomes like macrosomia and pregnancy-induced hypertension.Methods:535 singleton pregnant women who received systematic antenatal examination in People’s Hospital of Danyang from October 2013 to October 2015 were candidates.They were all<35 years old,gestational weeks<12 weeks during their first antenatal examination,with normal blood pressure,blood sugar,liver and kidney functions.After following inclusion and exclusion criteria,501 pregnant women were our final study sample size.Epidemiological data were collected by personal interview using questionnaires.Four lipid types:total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C)and low density lipoprotein cholesterol(LDL-C)during the first,second and third trimester were detected and recorded.The body weight gained during pregnancy,pregnancy complications,gestational age at delivery,means of delivery,placental weight,birth weight,Apgar score and 24 hours postpartum hemorrhage were all recorded.SPSS 21.0 statistical software was used to process the data.Correlation analysis was used to study the relationship between level of serum lipids during pregnancy and birth weight.Combined with epidemiological outcomes,Logistic regression analysis was used to explore the multiple factors affecting birth weight.Results:1.Compared to non-pregnant women,the levels of TC,TG,HDL and LDL were increased significantly in pregnant women,especially TG.2.Compared to normal pregnant women,the level of TG during the first,second and third trimester was increased in women with hypothyroidism during pregnancy,which decreased observably after thyroxine supplement.3.Compared to normal pregnant women,the level of TG in the first trimester was increased in women with gestational diabetes mellitus,but it showed no statistical significance in the second and third trimester.4.Compared to normal pregnant women,the level of TG in the first trimester was increased in women with pregnancy-induced hypertension,but it showed no significant increase in the second and third trimester.5.Compared to normal pregnant women,the level of TG in the first trimester was increased in women whose delivery outcome was macrosomia,but it showed no statistical significance in the second and the third trimester.6.Our result showed increasing birth weight increases both the amount of postpartum hemorrhage and the risk of head presentation dystocia.7.According to lipid level during the first,and the third trimester,it showed negative correlation between birth weight and the level of HDL in the second and third trimester,and the third trimester played a major role compared to the second.8.Logistic regression analysis showed correlation between birth weight and body weight gained during pregnancy,BMI,level of HDL in the second and third trimester and level of TG in the third trimester.Conclusions:1.Compared to non-pregnant,the levels of serum lipids are increased significantly during the first,second and third trimester,especially TG2.Increasing level of TG in the first trimester plays a role to predict effect of pregn ancy-induced hypertension,gestational diabetes mellitus and hypothyroidism during pregnancy.3.Hypothyroidism during pregnancy,pregnancy-induced hypertension and gestational diabetes mellitus can influence birth weight by affecting the level of serum lipids.4.It should be started in the first trimester to reduce the incidence rate of macrosomia.5.The increasing birth weight will increase the incidence rate of both postpartum hemorrhage and head presentation dystocia.