The Study On Facial Emotion Recognition,Attention Function And Event Related Potentials N170 In Patients With Cerebral Infarction In Basal Ganglia

Objective: To analyze the characteristics of facial emotional cognitive impairments and the correlation with attention,N170 in patients with cerebral infarction in basal ganglia.Methods: Thirty patients with cerebral infarction in basal ganglia were selected from the Department of Neurology of the Affiliated Hospital of Southwest Medical University(the group was hereinafter referred to as “C”group),at the same time,we selected thirty healthy patients in education,age,gender matched with “C” group as the normal control group(the group was hereinafter referred to as “N”group).The following tests were completed by “C” group and “N” group: 1.Three neuropsychological scale tests: Aactivities of Daily Living Scale(ADL),Montreal cognitive scale(Mo CA),Hamilton Depression Scale(HAMD);2.Computer auxiliary tests: Sustained attention:(Continuous Performance Test,CPT),Selective attention:(The Stroop Test,Stroop),Metastatic attention:(Trail Making Test-B,TMT-B),Divided attention:(Paced Auditory Serial Addition Test,PASAT),face emotional cognitive tests;3.Event related potentials(ERPs): N170.Correlation analyses between face emotional recognition and various attentive recognitions,ERPs were performed.Results: 1.There were no significant differences in education degree,age,sex between “N” group and “C” group(P>0.05).2.In Mo CA test,compared with “N”group,test scores were lower in “C” groups(P<0.01),there were significant differences in visual space cognitive/executive function,the level of abstraction,memory and attention level in the two groups(P<0.01),but there were no significant differences in rest of the single tests(P>0.05);3.Computer auxiliary testing results:(1)In CPT,“C” group compared with “N”group,the average reaction time and non-response rates increased,the differences were significant(P<0.05);(2)In Stroop,“C” group compared with “N” group,reaction time under conflict and neutral conditions,interfered effect of reaction time were prolonged,the error rate under conflict and neutral conditions,interfered effect of error rate were increased,but the differences were not significant(P>0.05);(3)In TMT-B,“C”group compared with “N” group,the time-consuming increased significantly(P<0.01);(4)In PASAT,“C” group compared with “N” group,the scores decreased significantly(P<0.01);(5)Face emotional recognition test: “C” group compared with “N” group,emotion recognition total scores,“disgust”,“surprised” were decreased significantly(P<0.05),the differences of the rest of the emotional faces were not significant.(P>0.05).4.ERPs :(1)The latency periods of N170: there were no significant differences in latency periods of N170 evoked by positive emotion,negative emotion and neutral emotion in “C” group(P>0.05);In“N” group,the latency periods of N170 had same consequence;“C” group compared with “N” group,latency periods of N170 evoked by positive emotion,negative emotion and neutral emotion were prolonged,but the differences were not significant(P>0.05).(2)The amplitudes of N170: In “C” group,the amplitude of N170 evoked by negative emotion compared with positive and neutral was decreased,with statistically differences(P<0.01),but there was no significant difference in positive and neutral emotion(P>0.05).In “N” group,the amplitude of N170 had same consequence;“C” group compared with “N” group,the amplitudes of N170 evoked by positive emotion and neutral emotion were decreased,but the differences were not significant(P>0.05),the amplitude of N170 evoked by negative emotion was decreased,the difference was significant(P<0.05).5.The correlation analysis: the total scores of emotion,"disgust","surprised" were negatively correlated with the non-response rates of CPT,the average reaction time of CPT and the time-consuming of TMT-B,and positively correlated with the scores of PASAT;“Happy” was negatively correlated with latency periods of N170 evoked by positive emotion,and positively correlated with amplitudes of N170 evoked by positive emotion;“Neutral” was negatively correlated with latency periods of N170 evoked by neutral emotion,and positively correlated with amplitudes of N170 evoked by neutral emotion;Scores of negative emotion,“disgust” and ”surprised” were negatively correlated with latency periods of N170 evoked by negative emotion,and positively correlated with amplitudes of N170 evoked by negative emotion;Conclusion: 1.Cognitive impairment in patients with cerebral infraction in basal ganglia mainly presented in attention,memory,visual space cognitive/executive function and the level of abstraction,sustained,metastatic and divided attentions damaged obviously,while selective attention already exist;2.Emotion "disgust","surprised" were affected mainly in patients with cerebral infraction in basal ganglia;3.Facial emotional recognition disorder may be affected by the attention function,possibly sustained,metastatic and divided attentions function;4.A good correlation was found between the N170 and emotional recognition,N170 could be used to detect emotional recognition impairment in Patients with cerebral infraction in basal ganglia,the amplitudes of N170 evoked by negative emotion was more sensitively in facial emotional cognition.