Evaluation Of Islet ?-cell And ?-cell Function At Different Level Of HbA1c In Patients With Newly Diagnosed Type 2 Diabetes Mellitus

Objective:To investigate the change of islet ?-cell and ?-cell function at different level of HbA1 c in patients with newly diagnosed T2 DM.Methods:A total of 269 newly diagnosed T2 DM patients were divided into four groups according to their HbA1 c level.Oral glucose tolerance test?OGTT?,insulin releasing test,and glucagon releasing.The islet ?-cell and ?-cell fuction was assayed by homeostasis model assessment for insulin resistance?HOMA-IR?,homeo stasis model assessment for ?-cell function?HOMA-??,early insulin secretion index??I30/?G30?,and second-phase insulin secretion index [using area under curve of insulin(AUC_INS)],glucagon,glucagon/insulin and area under curve of glucagon(AUC_glu)among the four groups,and a correlation analysis was performed between Hb A1 c and other indicators.Result:?1?There was a good correlation between Hb A1 c and pancreatic beta cells?p<0.05?,and there was no significant correlation between islet cells and pancreatic islets?p>0.05?.?2?Glucagon,AUCglu was no significant different and glucagon/insulin increased significantly?p<0.05?with the increase of Hb A1 c.Conclusion: There was no correlation between HbA1 c and the islet beta cells,but not with islet ?-cells.With the increase of Hb A1 c level,the secretion function of beta cells gradually decreased,ach phase to reduce the secretion of insulin,glucagon absolute value has no significant change,but glucagon / insulin ratio increases,exacerbated by elevated blood glucose in patients with type 2 diabetes.