The Relationship Between Threatened Abortion And The Outcome Of Coagulation And Fibrinolysis

Objective:Study on relationship between the blood coagulation fibrinolysis and threatened abortion outcomes and anti-beta2 glycoprotein I antibody.Methods: Ta-ken 78 cases who be diagnosed as threatened abortion patients in our hospital from December 2014 to December 2015 for example.For the case,there were 41 cases of patients with pregnancy after be treated in continue pregnancy group;they were 37 patients develop inevitable abortion in inevitable abortion group,therefore,selected 40 cases of normal pregnancy in our hospital as control group.Taken the vein blood from all the groups and had the vein blood from each group got the medical test on Fg,DD,PLT,PT,APTT,and had the threatened abortion patients got a medical test on anti-beta2 glycoprotein I antibody detection.Compared the le-vels of DD,Fg,PLT,PT and APTT between the pregnant women in each group,and analyzed the correlation between the indexes of coagulation and fibrinolysis a-nd anti-beta2 glycoprotein I.Results: Distinctly,the PLT,DD,Fg in inevitable ab-ortion group was higher than continuing pregnancy group and normal pregnancy g-roup,the difference was statistically significant(P<0.05);the PT,APTT on inevit-able abortion group was lower than the continuing pregnancy group and normal pr-egnancy group,the difference has statistically significant(P <0.05);made a comp-arison on the patients more than 12 W weeks of gestation,the DD,Fg in the patient-s of inevitable abortion group was higher than the pregnancy group,the PT,APTT decreased significantly,the difference was statistically significant(P<0.05);Patie-nts with abortion more than 2 times the number of times with< 2 PLT,DD,Fg increased significantly,the difference was statistically significant(P<0.05),APTT s-ignificantly decreased the difference was statistically significant(P<0.05),there w--as no significant difference of PT(P>0.05).Inevitable abortion group of anti-beta2 glycoprotein I antibody positive rate was significantly higher than that of the continuing pregnancy group,the difference was statistically significant(P<0.05),the Spearman correlation analysis,anti-beta2 glycoprotein I antibody,DD and Fg were positively correlated with APTT negative correlation(r=0.268,0.295,and-0.393,P<0.05).Conclusion: The imbalance of coagulation and fibrinolysis was related to the adverse pregnancy outcome of threatened abortion patients,anti-beta2-glycoprot-ein I antibody can affect the outcome of threatened abortion,the mechanism may be through the influence of maternal coagulation and fibrinolysis system.