Detection Of Vernonia Anthelmintica Willd Injection Lead To The Difference Of Silicosis Patients Serum Protein

Objesctive: To detect atomization inhalation of xinjiang uygur medicine vernonia anthelmintica willd injection lead to the difference of silicosis patients serum protein.Methods: Randomly selected 40 male patients in silicosis one stage from November 2014 to March 2017,the fifth affiliated hospital,xinjiang medical university.According to the proportion of 1:1 divided the patients into VAWI treatment group and foundation treatment group,each 20 cases,and the selection in the same period health physical examination of 20 cases as normal group.Foundation treatment group was given including oxygen therapy,relieving cough,eliminating phlegm,relieving asthma,anti-inflammatory and other conventional treatment,VAWI treatment group patients under the condition of foundation treatment group added to vernonia anthelmintica willd injection,given 2 ml VAWI join into the 10 ml of 0.9% saline by atomization inhalation.Two groups of treatment with 10 to 15 days.Extraction of two groups of patients before and after treatment and normal groups of centrifugal blood,take the serum,by surface enhanced laser desorption ionization time of flight mass spectrometry(SELDI TOF MS)technology to detect serum protein of the differences between the three groups.Results:The differences of age,body mass index,cultural level,smoking index with three groups had no statistical significance(p>0.05).Foundation treatment group before and normal group predict protein names are as follows: complement c3 frag?amyloid beta a4 protein?hepcidin?fibrinogen alpha chain frag?neurosecretory protein vgf frag?alpha-1-antichymotrypsin frag?apolipoprotein c-i?transthyretin?apolipoprotein c-iii?apolipoprotein a-ii?cystatin-c.Foundation treatment group after and normal group predict protein names are as follows: amyloid beta a4 protein?hepcidin?fibrinogen alpha chain frag?neurosecretory?alpha-1-antichymotrypsin frag ? apolipoprotein c-i ? transthyretin ? osteopontin frag ? apolipoprotein c-iii ?apolipoprotein a-ii?cystatin-c.Foundation treatment group before and after predict protein names are as follows: amyloid beta a4 protein?plasma protease c1 inhibitor frag?alpha-1-antichymotrypsin frag?neurosecretory protein vgf frag?fibrinogen alpha chain frag?osteopontin frag.VAWI treatment group before and after predict protein names are as follows: amyloid beta a4 protein?fibrinogen alpha chain frag?neutrophil defensin 1,neutrophil defensin 3?neurosecretory protein vgf frag?plasma protease c1 inhibitor frag?alpha-1-antichymotrypsin frag?apolipoprotein c-i?transthyretin?osteopontin frag?hemoglobin subunit beta?apolipoprotein a-ii?cystatin-c.Serum protein expression had statistical significance(p < 0.05,Variable Importance in the Projection > 1).Conclusion: The expression of serum protein in patients with silicosis who get foundation treatment before and normal healthy people are differences.The same to patients with silicosis who get foundation treatment after.The expression of serum protein in patients with silicosis who get foundation treatment before and after are differences.The expression of serum differential protein in patients with silicosis can be caused by vernonia anthelmintica willd injection.