Regularity Research On HIV/AIDS Inflammatory Itchy Skin Diseases Of TCM Syndrome In Yunnan Province

PurposeThe study of TCM syndrome between HIV-PPE and Eczema within HIV/AIDS associated inflammatory itchy skin disease,and the discussion of distribution law of TCM syndrome and characteristics of lesion between HIV-PPE and Eczema in Yunnan Province.MethodTo conduct the research over the HIV/AIDS patients in Outpatient Department and Inpatient Department of Yunnan AIDS Care Center,and also in Prison Administration Center Hospital of Yunnan Province,200 patients with HIV-PPE and 210 patients of Eczema were selected as samples to fill in the questionnaire of TCM syndrome of HIV/AIDS associated inflammatory itchy skin disease of TCM syndrome and quantification form of skin lesion.Recording CD₄⁺T lymphocyte count,tongue and pulses of the patients.Based on the symptoms,signs,and tongue and pulse characteristics of each HIV-PPE and Eczema patient,determining which TCM syndrome classification it belongs to.Result 1 HIV-PPE 1.1 200 HIV-PPE cases were collected during the study,among those 115 were male,85 were female.1.2 The distribution of TCM syndromes: 82 cases of blood deficiency wind dryness syndrome,70 cases of hot and humid immersed syndrome,28 cases of Qi stagnation and blood stasis syndrome,12 cases of fire poison main syndrome,8 cases of the wind and blood heat syndrome.There is no significant difference among the distribution of each TCM syndrome type in the CD₄⁺T lymphocyte count grading?P>0.05?.1.3 The CD₄⁺T lymphocyte count graded distribution statistics: 97 cases with CD₄⁺? 50 cells/ul,22 cases with 50 cells/ul<CD₄⁺?200 cells/ul,29 cases with 200 cells/ul<CD4 +?350 cells/ul,52 cases with CD₄⁺>350 cells/ul.1.4 All the patients of HIV-PPE in the study have symptoms of different level of itch,mainly in the level of moderate to severe.1.5 HIV-PPE lesions pathological changes are mainly papules and nodules.1.6 Analysis based on area of rash grading: the distribution of rash area in HIV-PPE is mainly lower than 29%,and there is no significant difference in the distribution of lesion area among all type of syndrome?P>0.05?.2 Eczema 2.1 210 eczema cases were collected during the study,among which 117 were male,93 were female.2.2 The distribution of TCM syndromes: 101 cases of hot and humid immersed syndrome,42 cases of Qi stagnation and blood stasis syndrome,31 cases of blood deficiency wind dryness syndrome,21 cases of the wind and blood heat syndrome,15 cases of fire poison main syndrome.There is no significant difference among the distribution of each TCM syndrome type in the CD₄⁺T lymphocyte count grading?P>0.05?.2.3 The CD₄⁺T lymphocyte count graded distribution statistics: 48 cases with CD₄⁺? 50 cells/ul,15 cases with 50 cells/ul<CD₄⁺?200 cells/ul,25 cases with 200 cells/ul<CD4 +?350 cells/ul,122 cases with CD₄⁺>350 cells/ul.2.4 All the patients of eczema in the study have symptoms of different level of itch,mainly in the level of moderate to severe.2.5 The main lesion type of eczema is epidermal exfoliation?scratch?and the skin seepage/ escharosis.2.6 Analysis based on area of rash grading: the distribution of rash area in eczema is between 10%-49%,and there is no significant difference in the distribution of lesion area among all type of syndrome?P>0.05?.3 Relevance between HIV-PPE and Eczema 3.1 There was no significant difference in gender,age and infection pathways between HIV-PPE and eczema?P>0.05?.3.2 There is significant difference in the CD₄⁺T lymphocyte count grading distribution between HIV-PPE and Eczema?P<0.05?.3.3 There is significant difference in distribution of lesion types between HIV-PPE and eczema.The severity of erythema,epidermal exfoliation?scratch?,and skin seepage/escharosis and lichenification in eczema is higher than in HIV-PPE.The severity of pimples/edema and nodules in HIV-PPE is higher than in eczema.Conclusion 1 HIV-PPE and eczema are common in the HIV related inflammatory skin disease.Although there is significant difference in lesion types and severity between HIV-PPE and eczema?P<0.05?,itch as the main clinical symptoms is shown in both,and itch in both is in moderate to severe level.This causes high influence to HIV/AIDS patient's daily life.2 In this study,regardless of the patient's immunological function in which stage,which is in every CD₄⁺T lymphocyte count stage,there is no significant difference in the distribution of TCM syndromes.Hot and humid immersed syndrome is proved to be the main syndrome types of eczema.Blood deficiency wind dryness syndrome,hot and humid immersed syndrome is proved to be the main syndrome types of HIV-PPE.3 There is a significant difference in the CD₄⁺T lymphocyte count between HIV-PPE and eczema?P<0.05?.The results of this study accord with the occurrence of HIV-PPE,which indicates that the immune system was seriously inhibited in HIV-infected and AIDS patients.4 The treatment such as clearing heat and removing damp,blood-activating and stasisdissolving promoting,driving the evil should be the main therapeutic principle in HIV related inflammatory skin diseases.It is also need to pay attention to the superficial and radical,and tonifying qi and nourishing blood.It is not only reliving skin rash and itch of HIV/AIDS associated inflammatory itchy skin disease patients,reducing the influence of which caused to their daily life,but also balancing Yin and Yang of their bodies,strengthening their disease resistance,and improving their quality of life and keeping better safety of patients.