Clinical Analysis Of 30 Cases With Dermatofibrosarcoma Protuberans

Objective Tumors showed as painless nodules or mass,some scars or atrophic plaques can be seen in local of these tumors.And the surface locally can be seen ulceration,crusting,hard texture.Tumors with or without outer membranes.Immunohistochemical staining showed that CD34,Vimentin staining was positive,CK,S-100 staining was negative.In recent years,with the exception of traditional and innovative surgical treatments new targeted therapies and other new adjuvant therapies have been used in DFSP,and has caused some new research and clinical interesting.Adjuvant treatment of DFSP includes radiation therapy(RT),traditional chemotherapy and molecular targeted therapy.According to analyze 30 cases of patients,which have been diagnosed dermatofibrosarcoma protuberance in clinical,the purpose is that through the clinical manifestations combined with histopathological examination and immunohistochemical staining,early clinical with benign tumors and other lesions phase identification,in order to further reduce the clinical misdiagnosis Rate,while emphasizing the importance of standard surgical treatment,and to explore the reduction of postoperative recurrence rate of new adjuvant therapy.Methods Clinical and laboratory data of 30 patients in Dalian area(1996-2015)with dermatofibrosarcoma(DFSP)were collected and analyzed,with complete histopathological examination,immunohistochemical staining and diagnosis and treatment.Statistical analysis of patients with first onset age,gender,course length,area,tumor number(single or multiple),tumor diameter,etc.Including 15 males and 15 females,male to female ratio of 1:1.The first onset of the minimum age of 5 years,maximum 79 years,mean age is 41 years.The histopathological and immunohistochemical results of the patients were analyzed statistically.Results 30 patients in this paper the ratio of male to female 1:1,the average age of 41 years.Early diagnosis of other lesions for more than 80%.Histopathological examination showed typical fusiform tumor cells were arranged in striated,radial arrangement.Immunohistochemical staining showed CD34,vimentin positive rate of 100%,CK,S-100 negative rate of 100%.Thirty patients underwent surgical resection,none of them received preoperative,intraoperative or postoperative adjuvant therapy.Among them,16 cases(53.3%)were treated by local excision(margin 1cm?2cm)(62.5%)relapsed,and 14 cases(46.7%)were treated with extensive resection(?3 cm margin).Two cases(14.3%)relapsed.Conclusinn In clinic DFSP easily confused with benign tumors and other lesions we can combined with histopathological examination and immunohistochemical staining,early diagnosis the disease in order to reduce the rate of clinical misdiagnosis further.Based on the extensive resection or Mohs technology,combined with a reasonable comprehensive treatment,such as radiation therapy(RT),traditional chemotherapy and molecular targeted therapy.lt will be to reduce the recurrence rate and improve patient prognosis.